Complicated multiple organ infection of Purpureocillium lilacinum and varicella-zoster virus infection in a patient with Evans’ syndrome  

作　　者：Xiangrong Hu Li Zhang Qingsong Lin Fengkui Zhang Xin Zhao 

机构地区：[1]State Key Laboratory of Experimental Hematology,National Clinical Research Center for Blood Diseases,Institute of Hematology and Blood Diseases Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Tianjin 300020,China

出　　处：《Blood Science》2022年第2期89-92,共4页血液科学（英文）

基　　金：This study was supported by Grant 18JCYBJC41200 of Tianjin Municipal Science and Technology Commission Grant.

摘　　要：Purpureocillium lilacinum(P lilacinum)is a rare pathogenic fungus,which mainly involves immunocompromised individuals.Here,we report a case of complicated multiple-organ infections involving skin,lungs,and spleen in a 63-year-old female with Evans’syndrome after 9 months of glucocorticoid treatment.Microbial examinations of skin biopsy and blood samples revealed Plilacinum infections.Posaconazole was effectivein this patient.During anti-fungitreatment,she developedvaricella-zoster virus infection and was diagnosed through next-generation sequencing examination.In conclusion,Plilacinum may affect different organ systems and is susceptible to posaconazole treatment.The molecular-based methods like microbial cell-free DNA sequencing could provide accurate and timely identification of a wide range of infections.

关 键 词：Evans’syndrome Fungal infection POSACONAZOLE Purpureocillium lilacinum Varicella-zoster virus 

分 类 号：R97[医药卫生—药品]