社会心理压力对儿童哮喘的影响及机制  

The effect of psychosocial stress on asthma in children and its mechanism

作　　者：朱贝贝(综述) 赵德育(审校)[1] Zhu Beibei;Zhao Deyu(Department of Respiratory Medicine,Children′s Hospital of Nanjing Medical University,Nanjing 210000,China)

机构地区：[1]南京医科大学附属儿童医院呼吸内科,210000

出　　处：《国际儿科学杂志》2022年第5期338-342,共5页International Journal of Pediatrics

摘　　要：随着对支气管哮喘(简称哮喘)认识的深入以及诊疗经验的累积,人们越来越意识到哮喘是一种异质性的身心疾病。社会心理压力可以增加儿童哮喘发作频率,加重家庭及社会负担。来自个人、家庭等层面的社会心理压力在大脑进行信号传导,信号传递至下游效应器,产生肾上腺皮质激素等效应因子,增强Th2、Th17型细胞反应,抑制Treg细胞反应,并影响哮喘相关遗传学。该文综述了社会心理压力影响哮喘的机制,以期更好的控制和治疗哮喘,提高哮喘患儿的生活质量。With the development of the understanding of bronchial asthma(asthma for short)and the accumulation of diagnosis and treatment experience,people realize that asthma is a heterogeneous physical and mental disease.Psychosocial stress can increase the frequency of asthma attacks in children and increase the burden of family and society.Psychosocial stress from individual,family and other levels transduces signals in the brain,which are transmitted to downstream effectors,producing effectors such as adrenocorticosteroids,enhancing Th2 and Th17 cell responses,inhibiting Treg cell responses,and influencing specific asthma related genotypes.This paper reviews the mechanism of psychosocial stress on asthma,in order to better control and treat asthma and improve the quality of life of children with asthma.

关 键 词：儿童 哮喘 社会心理压力 下丘脑-垂体-肾上腺轴 基因学 

分 类 号：R72[医药卫生—儿科]