淋巴细胞与中性粒细胞比值对食管鳞癌患者同步放化疗疗效及预后判断的临床意义  

Clinical significance of lymphocyte to neutrophil ratio in evaluating the efficacy and prognosis of concurrent radiotherapy and chemotherapy in patients with esophageal squamous cell carcinoma

作　　者：陈阳[1] 陈方[1] 施朕善[1] 王磊[1] CHEN Yang;CHEN Fang;SHI Zhenshan;WANG Lei(Oncology,Bozhou People's Hospital,Bozhou,Anhui,China,236800)

机构地区：[1]亳州市人民医院肿瘤科,安徽亳州236800

出　　处：《分子诊断与治疗杂志》2022年第7期1121-1124,共4页Journal of Molecular Diagnostics and Therapy

基　　金：中华国际医学交流基金会先声临床科研专项基金(Z-2014-06-18388)。

摘　　要：目的 探讨淋巴细胞与中性粒细胞比值(NLR)对食管鳞癌患者同步放化疗疗效及预后判断的价值。方法 选取2018年3月至2021年9月安徽省亳州市人民医院肿瘤科收治的122例食管鳞癌患者为研究对象,依据受试者工作特征曲线(ROC)中NLR最佳截断值分为低NLR组(n=82)及高NLR组(n=40)。分析放疗前NLR水平与食管癌患者同步放化疗疗效及预后之间的联系。结果 低NLR组患者临床有效率明显高于NLR组,差异有统计学意义(P<0.05);低NLR组与高NLR组患者间年龄、性别比较,差异无统计学意义(P>0.05),TNM分期具有统计学意义(P<0.05);Cox比例风险回归模型分析,影响患者预后的相关因素主要为NLR水平、TNM分期,多因素分析表明影响患者预后的独立危险因素为NLR水平、TNM分期;NLR对食管鳞癌预后具有一定的诊断价值(P<0.05)。结论 淋巴细胞与中性粒细胞比值对食管鳞癌患者同步放化疗疗效及预后具有一定的预测价值。Objective To investigate the value of lymphocyte to neutrophil ratio(NLR) in evaluating the efficacy and prognosis of concurrent radiotherapy and chemotherapy in patients with esophageal squamous cell carcinoma. Methods 122 patients with esophageal squamous cell carcinoma treated in the Oncology Department at Bozhou people ’ s Hospital of Anhui Province from March 2018 to September 2021were selected as the research objects. They were divided into the low NLR group(n=82)and the high NLR group(n=40)according to the best NLR cutoff value in the receiver operating characteristic curve(ROC). The relationship between NLR level before radiotherapy and the efficacy and prognosis of concurrent radiotherapy and chemotherapy in patients with esophageal cancer was analyzed. Results The clinical effective rate of patients in the low NLR group was significantly higher than that in the NLR group(P<0.05);There was no significant difference in age and sex between the low NLR group and the high NLR group(P>0.05),and TNM stage was statistically significant(P<0.05). Cox proportional hazard regression model analysis showed that the relevant factors affecting the prognosis of patients were NLR level and TNM stage. Multivariate analysis showed that the independent risk factors affecting the prognosis of patients were NLR level and TNM stage;NLR has certain diagnostic value for the prognosis of esophageal squamous cell carcinoma(P<0.05). Conclusion The ratio of lymphocyte to neutrophil has a certain predictive value for the efficacy and prognosis of concurrent radiotherapy and chemotherapy in patients with esophageal squamous cell carcinoma.

关 键 词：淋巴细胞与中性粒细胞比值 食管鳞癌 同步放化疗 预后 

分 类 号：R735.1[医药卫生—肿瘤]