CIP2A在下咽癌中的表达及临床意义  

Expression and clinical significance of CIP2A in hypopharyngeal carcinoma

作　　者：程瑶 张震 杨吉[2] 冯成敏 邓启成 张西 赵锐[1] 朱鑫[1] 吴俊志 刘海[1] 邓世山[3] CHENG Yao;ZHANG Zhen;YANG Ji;FENG Chengmin;DENG Qicheng;ZHANG Xi;ZHAO Rui;ZHU Xin;WU Junzhi;LIU Hai;DENG Shishan(Department of Otorhinolaryngology&Head and Neck Surgery,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,Sichuan,China;Department of Otorhinolaryngology&Head and Neck Surgery,Neijiang Second People's Hospital,Neijiang 641000,Sichuan,China;Department of Human Anatomy,North Sichuan Medical College,Nanchong 637000,Sichuan,China)

机构地区：[1]川北医学院附属医院耳鼻咽喉头颈外科,四川南充637000 [2]内江市第二人民医院耳鼻咽喉头颈外科,四川内江641000 [3]川北医学院人体解剖学教研室,四川南充637000

出　　处：《山东大学耳鼻喉眼学报》2022年第2期40-44,共5页Journal of Otolaryngology and Ophthalmology of Shandong University

基　　金：四川省医学青年创新科研课题计划(S19055)。

摘　　要：目的探讨下咽癌组织中蛋白磷酸酶2A的癌性抑制因子(CIP2A)的表达与患者临床病理特征和预后的关系。方法于川北医学院附属医院病理科收集2016年1月至2020年12月下咽癌组织标本共58例,其中配对癌旁组织标本20例,同时选取30例正常下咽组织纳入分析。结果免疫组化SP显示,CIP2A在下咽癌组织中的表达水平显著高于在癌旁及正常下咽组织中的表达水平(P<0.001)。CIP2A的表达与患者是否饮酒、病理分化程度、临床分期、是否有淋巴结转移有明显关系(P<0.05),而与性别、年龄、是否吸烟、临床分型无明显关系。单因素Log⁃rank检验分析显示患者年龄、临床分期、CIP2A表达与患者预后相关(P<0.05)。进一步Cox风险比例回归模型分析发现CIP2A表达是影响下咽癌预后的独立危险因素。结论蛋白磷酸酶2A的癌性抑制因子CIP2A在下咽癌组织中异常表达提示其可能参与了肿瘤的发生发展,CIP2A高表达的下咽癌患者预后较差,故CIP2A有望成为下咽癌患者诊断、治疗与预后的分子标志物之一。Objective To investigate the relationship between the expression of protein phosphatase 2A(CIP2A)and the clinico⁃pathological features and prognosis of hypopharyngeal carcinoma.Methods Tissue samples from 58 patients with hypopharyngeal cancer,including 20 cases with paired paracarcinoma tissue samples,were collected in the Department of Pathology,Affiliated Hos⁃pital of North Sichuan Medical College from January 2016 to December 2020;30 normal hypopharyngeal tissue samples were selected for comparison.Results Immunohistochemical SP showed that the expression level of CIP2A in hypopharyngeal carcinoma tissue was significantly higher than that in paracarcinoma and normal hypopharyngeal tissue(P<0.001).CIP2A expression was signifi⁃cantly related to alcohol consumption,pathological differentiation,clinical stage and lymph node metastasis(P<0.05),but had no significant relationship with gender,age,smoking status,or clinical type.Univariate log⁃rank analysis showed that age,clinical stage and CIP2A expression were correlated with prognosis(P<0.05).Cox proportional regression model analysis revealed that CIP2A expression was an independent risk factor for the prognosis of hypopharyngeal cancer.Conclusion The abnormal expression of CIP2A in hypopharyngeal cancer tissue suggests that this protein may be involved in the occurrence and development of tumors.Patients with hypopharyngeal cancer with high expression of CIP2A have a poor prognosis.Therefore,CIP2A may be a useful molecular marker for diagnosis,treatment and prognosis of hypopharyngeal cancer patients.

关 键 词：下咽癌 CIP2A 免疫组化 预后 

分 类 号：R739.6[医药卫生—肿瘤]