肝脏超声造影及TK1、AFP对肝脏局灶性结节性病变良恶性分析价值  

Value of Hepatic Contrast-enhanced Ultrasound and TK1,AFP in Benign and Malignant Analysis of Hepatic Nodular Lesions

作　　者：任素芬 Ren Sufen(Department of Ultrasound,Fan County People's Hospital,Puyang,Henan Province,Puyang 457500)

机构地区：[1]河南省濮阳市范县人民医院超声科,濮阳457500

出　　处：《数理医药学杂志》2022年第8期1111-1114,共4页Journal of Mathematical Medicine

摘　　要：目的:分析肝脏超声造影及胸苷激酶1(Thymidine kinase 1,TK1)、甲胎蛋白(alpha fetoprotein,AFP)对肝脏局灶性结节性病变良恶性诊断价值。方法:选取2018年9月-2020年9月某院收治肝脏局灶性结节性病变患者128例(128个病灶)均行超声造影及血清TK1、AFP检查,以穿刺活检结果作为“金标准”,分析3种检查方法在肝脏局灶性结节性病变良恶性中的诊断价值。结果:超声造影、血清TK1、AFP联合检测肝脏局灶性结节性病变良恶性的准确度(95.31%)、敏感度(97.30%)、特异度(92.59%)、约登指数(0.899)、阳性预测值(94.74%)、阴性预测值(96.15%)明显高于单独检测。超声造影检测准确度91.41%、敏感度93.24%、特异度88.89%、约登指数0.821、阳性预测值92.00%、阴性预测值92.57%。血清TK1检测准确度85.94%、敏感度89.19%、特异度81.48%、约登指数0.707、阳性预测值84.62%、阴性预测值85.94%。血清AFP检测准确度86.72%、敏感度86.49%、特异度87.04%、约登指数0.735、阳性预测值90.14%、阴性预测值82.46%。结论:肝脏超声造影及TK1、AFP联合诊断对肝脏局灶性结节性病变良恶性诊断价值高于单独肝脏超声造影及TK1、AFP检查,能够弥补单项诊断的不足之处。Objective:To analyze the value of contrast-enhanced ultrasound,thymidine kinase 1(TK1)and alpha fetoprotein(AFP)in the diagnosis of benign and malignant hepatic nodular lesions.Methods:From September 2018 to September 2020,128 patients(128 lesions)with hepatic local nodular lesions were selected and examined by contrast-enhanced ultrasound and serum TK1 and AFP.The results of needle biopsy were used as the gold standard to analyze the diagnostic value of the three examination methods in benign and malignant hepatic local nodular lesions.Results:The accuracy(95.31%),sensitivity(97.30%),specificity(92.59%),Youden index(0.899),positive predictive value(94.74%)and negative predictive value(96.15%)of combined detection of contrast-enhanced ultrasound,and serum TK1 and AFP in the diagnosis of benign and malignant hepatic nodular lesions were significantly higher than those of single detection.The accuracy,sensitivity,specificity,Youden index,positive predictive value,and negative predictive value in the contrast-enhanced ultrasound were 91.41%,93.24%,88.89%,0.821,92.00%,and 92.57%,respectively.The accuracy,sensitivity,specificity,Youden index,positive predictive value and negative predictive value of serum TK1 detection were 85.94%,89.19%,81.48%,0.707,84.62% and 85.94%,respectively.The accuracy,sensitivity,specificity,Youden index,positive predictive value and negative predictive value of serum AFP were 86.72%,86.49%,87.04%,0.735,90.14% and 82.46%,respectively.Conclusion:The value of combined detection of contrast-enhanced ultrasound,and TK1,AFP in the diagnosis of benign and malignant hepatic nodular lesions is higher than that of contrast-enhanced ultrasound,TK1 and AFP alone,which can make up for the shortcomings of single diagnosis.

关 键 词：超声造影 胸苷激酶1 甲胎蛋白 肝脏局灶性结节性病变 

分 类 号：R575[医药卫生—消化系统]