New developments in the treatment of cutaneous leishmaniasis  

作　　者：Rasit Dinc 

机构地区：[1]Invamed RD Global,Ankara,Turkey

出　　处：《Asian Pacific Journal of Tropical Medicine》2022年第5期196-205,共10页亚太热带医药杂志（英文版）

摘　　要：Leishmaniasis,including the cutaneous form,poses an important public health threat around the world,while no vaccine is currently available against any form of leishmaniasis.The drugs used in the first line treatment of cutaneous leishmaniasis(CL)are commonly pentavalent antimonials despite their toxicities,long-term treatment duration and increasing resistance rates.Other alternatives are amphotericin B,pentamidine,miltefosine and paromomycine.Movement of the population,especially in endemic regions,increases the spread of the parasite and affectes the distribution of causative species,which requires re-evaluation the treatment regimen.Extensive researches are carried out on the treatment of leishmaniasis.The immunotherapeutic and targeted therapeutic approaches,formulations of carrier-loaded active drugs,local thermotherapeutic applications,the combination of antileishmanial drugs/compounds,the use of new synthetic and natural products are promising therapeutic options in the future.Herein,the author reviews the potential treatment modalities of CL with a brief overview of current treatments in the light of ongoing studies around the world.

关 键 词：Cutaneous leishmaniasis Current treatment Potential treatments THERMOTHERAPY IMMUNOTHERAPY Natural/synthetic therapy 

分 类 号：R531.6[医药卫生—内科学]