丁苯酞联合阿司匹林及阿托伐他汀治疗脑梗死的疗效观察  

Efficacy observation of butylphthalide combined with aspirin and atorvastatin in the treatment of cerebral infarction

作　　者：叶雪科 YE Xue-ke(Department One of Internal Medicine,Luhe County People's Hospital,Shanwei 516700,China)

机构地区：[1]陆河县人民医院内一科,516700

出　　处：《中国现代药物应用》2022年第12期11-14,共4页Chinese Journal of Modern Drug Application

摘　　要：目的探讨丁苯酞联合阿司匹林及阿托伐他汀治疗脑梗死的临床疗效。方法70例脑梗死患者为研究对象,采用随机数字表法分为治疗组与对照组,各35例。对照组给予阿司匹林联合阿托伐他汀治疗,治疗组给予丁苯酞联合阿司匹林及阿托伐他汀治疗。比较两组治疗前后神经功能、日常生活活动能力、氧化应激指标[血清超氧化物岐化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、一氧化氮(NO)]、治疗效果及不良反应发生情况。结果治疗后,治疗组美国国立卫生研究院卒中量表(NIHSS)评分(9.54±1.63)分低于对照组的(17.69±3.20)分,日常生活活动能力量表(ADL)评分(85.02±5.67)分高于对照组的(72.64±8.44)分,差异均有统计学意义(P<0.05)。治疗组治疗总有效率94.29%高于对照组的77.14%,差异有统计学意义(P<0.05)。治疗后,治疗组SOD为(121.33±11.62)U/ml、GSH-Px为(123.52±12.15)U/L明显高于对照组的(98.68±10.71)U/ml、(110.82±13.33)U/L,NO(36.74±4.83)μmol/L明显低于对照组的(53.57±6.42)μmol/L,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论脑梗死患者接受丁苯酞联合阿司匹林及阿托伐他汀治疗,整体疗效显著,安全性理想。Objective To discuss the clinical efficacy of butylphthalide combined with aspirin and atorvastatin in the treatment of cerebral infarction.Methods A total of 70 patients with cerebral infarction were selected as the research subjects,and the patients were divided into treatment group and control group by random numerical table,with 35 cases in each group.The control group was treated with aspirin and atorvastatin,and the treatment group was treated with butylphthalide combined with aspirin and atorvastatin.The neurological function,activities of daily living,and oxidative stress indexes[superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),nitric oxide(NO)]before and after treatment,therapeutic effect,and occurrence of adverse reactions were compared between the two groups.Results After treatment,the National Institutes of Health stroke scale(NIHSS)score(9.54±1.63)points in the treatment group was lower than(17.69±3.20)points in the control group,and the activities of daily living(ADL)score(85.02±5.67)points was higher than(72.64±8.44)points in the control group.All the differences were statistically significant(P<0.05).The total effective rate 94.29% of the treatment group was higher than 77.14% of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of SOD(121.33±11.62)U/ml and GSH-Px(123.52±12.15)U/L in the treatment group were significantly higher than(98.68±10.71)U/ml and(110.82±13.33)U/L in the control group,and the NO(36.74±4.83)μmol/L was significantly lower than(53.57±6.42)μmol/L in the control group.All the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Butylphthalide combined with aspirin and atorvastatin in the treatment of cerebral infarction has significant overall efficacy and ideal safety on patients with cerebral infarction.

关 键 词：丁苯酞注射液 阿司匹林肠溶片 阿托伐他汀片 脑梗死 临床疗效 

分 类 号：R743.33[医药卫生—神经病学与精神病学]