马铃薯中氟吡菌胺、氰霜唑及相关代谢物的残留量及膳食风险评估  

Residues and dietary risk assessment of fluopicolide, cyazofamid and related metabolites in potato

作　　者：秦世鹏 胡继业[1] QIN Shi-peng;HU Ji-ye(School of Chemistry and Biological Engineering,University of Science and Technology Beijing,Beijing 100083,China)

机构地区：[1]北京科技大学化学与生物工程学院,北京100083

出　　处：《农药》2022年第7期500-506,512,共8页Agrochemicals

摘　　要：[目的]旨在研究氟吡菌胺和氰霜唑在田间条件下马铃薯中的残留行为,并评估其慢性膳食风险。[方法]按照良好农业规范(GAP),在中国12地马铃薯主产区开展了30%氟吡菌胺·氰霜唑悬浮剂(15%氟吡菌胺+15%氰霜唑)在马铃薯上的残留田间试验。在马铃薯晚疫病发病初期,以157.5 g a.i./hm^(2)的剂量喷洒该制剂3次,施药间隔7 d,推荐安全间隔期(PHI)为7 d。采用QuEChERS和高效液相色谱串联质谱同时检测了田间马铃薯样品中氟吡菌胺、2,6-二氯苯甲酰胺、氰霜唑和CCIM的残留水平。根据田间试验结果、毒理学数据和中国居民膳食结构,分别对马铃薯中的氟吡菌胺、2,6-二氯苯甲酰胺、氰霜唑进行了慢性膳食风险评估。[结果]氟吡菌胺、2,6-二氯苯甲酰胺、氰霜唑和CCIM在马铃薯中的平均回收率为87%~98%,相对标准偏差为1.9%~6.7%,氟吡菌胺和2,6-二氯苯甲酰胺的定量限为0.02 mg/kg,氰霜唑和CCIM的定量限为0.01 mg/kg。田间试验结果表明:在距最后1次施药后7、10 d收获的马铃薯样品中,氟吡菌胺和2,6-二氯苯甲酰胺的最终残留量均低于0.02 mg/kg,氰霜唑和CCIM的最终残留量均低于0.01 mg/kg,同时也均低于中国在马铃薯上制定的最大残留限量(MRL,氟吡菌胺:0.05 mg/kg;氰霜唑:0.02 mg/kg)。氟吡菌胺、2,6-二氯苯甲酰胺和氰霜唑的慢性风险商均≤9.11%,对消费者造成的健康风险较低。[结论]按照GAP条件(施药剂量76.5~157.5 g a.i./hm^(2),喷施2~3次,施药间隔期7~10 d)在田间马铃薯上施用该制剂,将PHI设定为7 d是安全的,为氟吡菌胺和氰霜唑在马铃薯上的合理使用提供指导。[Aims] This paper aims to research the residue behavior of fluopicolide and cyazofamid in potato under field conditions and to evaluate the chronic dietary risk. [Methods] In accordance with Good Agricultural Practices(GAP),the field trials of 30% suspension concentrate(SC, fluopicolide 15% +cyazofamid 15%) on potato were carried out across 12 main potato producing regions of China in this study. The formulation was sprayed at the dosage of 157.5 g a.i./ha for 3 times with an interval of 7 d in the initial stage of potato late blight, and the recommended pre-harvest interval(PHI) was 7 d. The residue levels of fluopicolide, 2,6-dichlorobenzamide, cyazofamid and CCIM in field potato samples were determined simultaneously using QuEChERS and high-performance liquid chromatography-tandem mass spectrometry. The chronic dietary risk assessments of fluopicolide, 2,6-dichlorobenzamide and cyazofamid in potato were carried out based on field trial results, toxicological data and Chinese dietary pattern, respectively. [Results] The mean recoveries of fluopicolide, 2,6-dichlorobenzamide, cyazofamid and CCIM in potato were 87%-98% with relative standard deviations(RSDs) of 1.9%-6.7%. The limits of quantification(LOQs) were 0.02 mg/kg for fluopicolide and2,6-dichlorobenzamide, and 0.01 mg/kg for cyazofamid and CCIM. The field trial results showed that the terminal residues in potato samples at 7 and 10 days after the last application were below 0.02 mg/kg for fluopicolide and 2,6-dichlorobenzamide, and below 0.01 mg/kg for cyazofamid and CCIM, which were lower than the maximum residue limit(MRL) on potato set by China(fluopicolide: 0.05 mg/kg, cyazofamid: 0.02 mg/kg). The chronic risk quotients of fluopicolide, 2,6-dichlorobenzamide and cyazofamid were all ≤9.11%, indicating a low risk to consumers′ health.[Conclusions] Applying the formulation on field potato under GAP conditions(76.5-157.5 g a.i./ha, 2-3 applications at an interval of 7-10 d), the recommended PHI of 7 d was safe. This study could provide guidance for th

关 键 词：氟吡菌胺 氰霜唑 代谢物 马铃薯 残留 膳食风险评估 

分 类 号：TQ450.2[化学工程—农药化工]