纯钛表面微弧氧化联合氯化钙微波水热涂层的体外活性研究  

In vitro activity of microarc oxidation combined with calcium chloride microwave hydrothermal coating on pure titanium surface

作　　者：邓萌 王天琦 张雨晗 谢伟丽[1] DENG Meng;WANG Tian-qi;ZHANG Yu-han;XIE Wei-li(Department of Prosthodontics,College of Stomatology of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属口腔医学院修复科,黑龙江哈尔滨150001

出　　处：《哈尔滨医科大学学报》2022年第2期107-111,共5页Journal of Harbin Medical University

基　　金：黑龙江省科技计划项目(GC12C305-3)。

摘　　要：目的研究纯钛表面微弧氧化联合以不同浓度氯化钙(CaCl)溶液为反应液微波水热制备涂层的微观结构及其在模拟体液中诱导磷灰石形成的能力。方法将32个加工成10 mm×10 mm×1 mm规格的纯钛试件随机分为4组,每组8个,对照组(MAO组)试件进行表面微弧氧化处理,实验组试件在表面微弧氧化处理后,以低(MH-L组)、中(MH-M组)、高(MH-H组)三种不同浓度CaCl溶液为反应液,进行微波水热处理,用扫描电子显微镜(scanning electron microscope,SEM)对试件表面结构进行观察,将各组试件浸泡于模拟体液(simulated body fluid,SBF)中,一段时间后取出,计算试件质量增量并观察表面形貌,用X射线衍射仪(X-ray diffraction,XRD)检测其表面形成的沉积物,分析其磷灰石诱导形成能力。结果MAO组可见试件表面形成大量孔洞结构,实验组各组试件表面形成了一定量的棒状纳米结构,经模拟体液浸泡后,各实验组试件表面沉积羟基磷灰石,且随着氯化钙反应液浓度升高,沉积物增多(P<0.01)。结论纯钛种植体进行表面微弧氧化联合氯化钙微波水热处理后具有良好的体外磷灰石诱导形成能力。Objective To study the microarc oxidation of pure titanium surface combined with different concentrations of calcium chloride(CaCl) solution as the reaction liquid microwave hydrothermal preparation of the microstructure of the coating and its ability to induce apatite formation in simulated body fluids. Methods Thirty-two pure titanium specimens with the specification of 10 mm×10 mm×1 mm were processed and randomly divided into 4 groups, 8 specimens in each group. The specimens in the control group(MAO group) were treated with surface microarc oxidation. After surface microarc oxidation, the specimens in the experimental group were treated with microwave hydrothermal treatment using three different concentrations of CaClsolutions: low(MH-L group), medium(MH-M group), and high(MH-H group). The surface structure of the specimens was observed by scanning electron microscope(SEM). The specimens in each group were soaked in simulated body fluid(SBF) and removed after a period of time. The mass increment of the specimens was calculated and the surface morphology was observed. The deposits formed on the surface were detected by X-ray diffraction(XRD) to analyze their apatite-induced formation ability. Results The surface of the MAO group formed a porous structure after treatment, and the surface of each experimental group formed apatite nanorods on the porous structure. After being immersed in simulated body fluid, hydroxyapatite was deposited on the surface of each group of specimens, and as the concentration of the calcium chloride reaction solution increased, the deposits increased(P<0.01). Conclusion The pure titanium implants after surface microarc oxidation combined with calcium chloride microwave hydrothermal treatment have good in vitro apatite formation ability.

关 键 词：钛 微弧氧化 微波水热 涂层 模拟体液 

分 类 号：R783.4[医药卫生—口腔医学]