5-HTT基因rs6354多态性与家庭因素对蒙古族学龄儿童适应性的影响  

The interaction between 5-HTT gene rs6354 polymorphism and family factors on the adaptability of Mongolian school-age children

作　　者：肖阳 赵曼 杨伊生 恩和巴雅尔[1] 李玉玲[1] Xiao Yang;Zhao Man;Yang Yisheng;Enhebayaer;Li Yuling(Institute of Life Science and Technology,Inner Mongolia Normal University,Hohhot 010022,China;Institute of Educational Science,Inner Mongolia University for Nationalities,Tongliao 028000,China;Institute of Psychology,Inner Mongolia Normal University,Hohhot 010022,China)

机构地区：[1]内蒙古师范大学生命科学与技术学院,呼和浩特010022 [2]内蒙古民族大学教育科学学院,通辽028000 [3]内蒙古师范大学心理学院,呼和浩特010022

出　　处：《中华行为医学与脑科学杂志》2022年第6期548-552,共5页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家自然科学基金(31260265);内蒙古自治区自然科学基金(2019MS08166)。

摘　　要：目的探讨5-羟色胺转运体(5-hydroxytryptamine transporter,5-HTT)基因rs6354多态性与家庭因素对蒙古族学龄儿童适应性的影响。方法采用8~12岁儿童气质问卷(middle childhood temperament questionnaire,MCTQ)对453名小学生进行适应性测评,利用改良多重连接酶检测反应(improved multiple ligase detection reaction,iMLDR)技术对5-HTT基因rs6354多态性进行分型,并使用SPSS 18.0统计软件进行数据处理与分析。结果(1)5-HTT基因rs6354位点为GG/GT和TT基因型的儿童适应性得分分别为(2.88±0.73)分和(3.03±0.76)分。(2)单因素分析显示,蒙古族学龄儿童适应性得分在父母受教育水平方面差异有统计学意义(父亲F=2.580,P=0.037;母亲F=3.245,P=0.012)。(3)多元回归分析显示,母亲受教育水平(B=-0.079,P=0.010)、rs6354多态性(B=0.165,P=0.041)是蒙古族学龄儿童适应性得分的影响因素。(4)Logistic回归分析显示,父亲受教育水平高低是蒙古族学龄儿童适应性高低的影响因素(B=0.453,P<0.05,OR=1.573,95%CI=1.023~2.417)。结论rs6354多态性与儿童适应性呈弱相关,父母、特别是父亲受教育水平可能是影响蒙古族学龄儿童适应性的重要因素。Objective To explore the effects of rs6354 polymorphism of 5-HTT gene and family factors on the adaptability of Mongolian school-age children.Methods The adaptability of 453 primary school students was assessed based on the middle childhood temperament questionnaire(MCTQ).The polymorphism of 5-HTT gene rs6354 was determined by improved multiple ligase detection reaction(iMLDR)technology.SPSS18.0 statistical software was used for data processing and analysis.Results(1)The adaptability scores of children with GG/GT and TT genotype at rs6354 locus of 5-HTT gene were(2.88±0.73)and(3.03±0.76).(2)Univariate analysis showed that the adaptability scores of Mongolian school-age children were significantly different among different education levels of their parents(father F=2.580,P=0.037;mother F=3.245,P=0.012).(3)Multiple regression analysis showed that mother's educational level(B=-0.079,P=0.010)and rs6354 polymorphism(B=0.165,P=0.041)were inflencing factors of the adaptability score of Mongolian school-age children.(4)Logistic regression analysis showed that father's education level was a significant impact factor of the adaptive level of Mongolian school-age children(B=0.453,P<0.05,OR=1.573,95%CI=1.023-2.417).Conclusion rs6354 polymorphism is weakly correlated with children's adaptability,and the education level of parents,especially fathers,may be an important factor affecting the adaptability of Mongolian school-age children.

关 键 词：气质 适应性 基因多态性 rs6354 学龄儿童 

分 类 号：R394[医药卫生—医学遗传学]