^(18)F-FDG PET/CT对慢性淋巴细胞白血病Richter综合征的诊断价值  

Diagnostic value of ^(18)F-FDG PET/CT for Richter syndrome of chronic lymphocytic leukemia

作　　者：蒋冲 滕月 来瑞鹤 丁重阳[2] Jiang Chong;Teng Yue;Lai Ruihe;Ding Chongyang(Department of Nuclear Medicine,Nanjing Drum Tower Hospital,the Affiliated Hospital of Nanjing University Medical School,Nanjing 210008,China;Department of Nuclear Medicine,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京大学医学院附属鼓楼医院核医学科,南京210008 [2]南京医科大学第一附属医院核医学科,南京210029

出　　处：《中华核医学与分子影像杂志》2022年第7期397-400,共4页Chinese Journal of Nuclear Medicine and Molecular Imaging

摘　　要：目的探索^(18)F-FDG PET/CT在慢性淋巴细胞白血病(CLL)患者Richter综合征(RS)诊断中的价值。方法回顾性分析2010年8月至2019年11月间在南京鼓楼医院和南京医科大学第一附属医院病理确诊的101例CLL患者[男62例、女39例,年龄(58.0±12.7)岁]的^(18)F-FDG PET/CT影像资料。勾画患者病灶ROI,记录SUV_(max)。采用Mann-Whitney U检验比较RS患者与非RS患者间SUV_(max)的差异,通过ROC曲线分析获得SUV_(max)预测RS的最佳阈值。结果27例CLL患者病理证实为RS。RS患者的SUV_(max)为13.7(11.0,20.1),明显高于非RS患者[4.1(3.1,5.8);z=-6.48,P<0.001]。ROC曲线分析示SUV_(max)的最佳阈值为10.0,AUC为0.923,诊断RS的准确性为94.1%(95/101)、灵敏度为85.2%(23/27)、特异性为97.3%(72/74)、阳性预测值为92.0%(23/25)、阴性预测值为94.7%(72/76)。结论^(18)F-FDG PET/CT半定量指标SUV_(max)在CLL患者RS诊断中具有较高准确性。Objective To explore the value of ^(18)F-FDG PET/CT in detecting Richter syndrome(RS)in chronic lymphocytic leukemia(CLL)patients.Methods From August 2010 to November 2019,101 histologically confirmed CLL patients(62 males,39 females;age(58.0±12.7)years)who underwent PET/CT in Nanjing Drum Tower Hospital and the First Affiliated Hospital of Nanjing Medical University were retrospectively included.ROI was drawn and PET/CT images were semi-quantitatively examined by estimating SUV_(max).Mann-Whitney U test was used to compare the SUV_(max) of RS and non-RS patients.ROC curve analysis was utilized to analyze the optimal cut-off value of SUV_(max) in detecting RS.Results RS was histologically confirmed in 27 CLL patients.The SUV_(max) of RS patients was 13.7(11.0,20.1),which was significantly higher than that of non-RS patients(4.1(3.1,5.8);z=-6.48,P<0.001).ROC curve analysis identified the optimal cut-off value of SUV_(max) was 10.0 and the AUC was 0.923,with accuracy of 94.1%(95/101),sensitivity of 85.2%(23/27),specificity of 97.3%(72/74),positive predictive value of 92.0%(23/25)and negative predictive value of 94.7%(72/76).Conclusion As the semi-quantitative index measured by ^(18)F-FDG PET/CT,SUV_(max) can help to diagnose RS and provide important information for clinical use.

关 键 词：白血病 淋巴细胞 慢性 B细胞 综合征 正电子发射断层显像术 体层摄影术 X线计算机 氟脱氧葡萄糖F18 

分 类 号：R733.72[医药卫生—肿瘤]