Dissecting the Neural Circuitry for Pain Modulation and Chronic Pain:Insights from Optogenetics  

作　　者：Fang Guo Yu Du Feng-Hui Qu Shi-Da Lin Zhong Chen Shi-Hong Zhang 

机构地区：[1]Department of Pharmacology and Department of Anesthesiology of the Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310058,China [2]Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province,College of Pharmaceutical Sciences,Zhejiang Chinese Medical University,Hangzhou 310053,China

出　　处：《Neuroscience Bulletin》2022年第4期440-452,共13页神经科学通报（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China(82073819 and 81872843);Fundamental Research Funds for the Central Universities of China(2021QNA7005).

摘　　要：Pain is an unpleasant sensory and emotional experience associated with,or resembling that associated with,actual or potential tissue damage.The processing of pain involves complicated modulation at the levels of the periphery,spinal cord,and brain.The pathogenesis of chronic pain is still not fully understood,which makes the clinical treatment challenging.Optogenetics,which combines optical and genetic technologies,can precisely intervene in the activity of specific groups of neurons and elements of the related circuits.Taking advantage of optogenetics,researchers have achieved a body of new findings that shed light on the cellular and circuit mechanisms of pain transmission,pain modulation,and chronic pain both in the periphery and the central nervous system.In this review,we summarize recent findings in pain research using optogenetic approaches and discuss their significance in understanding the pathogenesis of chronic pain.

关 键 词：OPTOGENETICS Pain transmission Pain modulation Chronic pain Neural circu 

分 类 号：R338.3[医药卫生—人体生理学]