Facile preparation of^(177)Lu-microspheres for hepatocellular carcinoma radioisotope therapy  

作　　者：Manran Wu Kexin Shi Ruizhe Huang Chunyi Liu Lingling Yin Weipeng Yong Jing Sun Guanglin Wang Zhiyuan Zhong Mingyuan Gao 

机构地区：[1]State Key Laboratory of Radiation Medicine and Protection,School of Radiation Medicine and Protection&School for Radiological and Interdisciplinary Sciences(RAD-X),Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions,Soochow University,Suzhou 215123,China [2]Biomedical Polymers Laboratory,College of Chemistry,Chemical Engineering and Materials Science,State Key Laboratory of Radiation Medicine and Protection,Soochow University,Suzhou 215123,China

出　　处：《Chinese Chemical Letters》2022年第7期3492-3496,共5页中国化学快报（英文版）

基　　金：the financial support from the National Natural Science Found of China(Nos.81720108024,21976128);Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD);the support from the Natural Science Foundation of Jiangsu Province(No.BK20200100)。

摘　　要：As one of the most common cancers in the world,hepatocellular carcinoma(HCC)has become a major threat to human health.Radioembolization is a first-line option for the treatment of HCC,especially when other conventional treatments fail or there exist some relative contraindications.Herein,we developed a facile and efficient method for preparing ^(177)Lu-microspheres potentially useful for precise radioembolization therapy of HCC.The radiolabeling efficiency of ^(177)Lu-microspheres was as high as 96.8%±0.5%,and the radiolabeling process did not alter the morphology of the mother microspheres.The SPECT/CT studies enabled by the unique emissions of ^(177)Lu suggested that almost no ^(177)Lu ion loaded by the microspheres was released over more than 32 d in vivo,which led to remarkable inhibition effect on the growth of HepG2 tumors subcutaneously transplanted in mice.The current approach may thus offer promising ^(177)Lu-microspheres for clinical radioembolization of HCC.

关 键 词：RADIOISOTOPE Radioactive microspheres Hepatocellular carcinoma SPECT/CT Radioembolization therapy 

分 类 号：R735.7[医药卫生—肿瘤]