ssDNA functionalized nanodiamonds for uranium decorporation  

作　　者：Qinglong Yan Yu Miao Xiaomei Wang Jifei Ma Juan Diwu Ying Zhu Shuao Wang Chunhai Fan 

机构地区：[1]Interdisciplinary Research Center,Shanghai Synchrotron Radiation Facility,Zhangjiang Laboratory,Shanghai Advanced Research Institute,Chinese Academy of Sciences,University of Chinese Academy of Sciences,Shanghai 201210,China [2]Shanghai Institute of Applied Physics,Chinese Academy of Sciences,Shanghai 201800,China [3]State Key Laboratory of Radiation Medicine and Protection,School for Radiological and Interdisciplinary Sciences(RAD-X)and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions,Soochow University,Suzhou 215123,China [4]School of Chemistry and Chemical Engineering,Frontiers Science Center for Transformative Molecules and National Center for Translational Medicine,Shanghai Jiao Tong University,Shanghai 200240,China

出　　处：《Chinese Chemical Letters》2022年第7期3570-3572,共3页中国化学快报（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China(Nos.82050005,21976127,22022410);the Youth Innovation Promotion Association of CAS(No.2016236);the Natural Science Foundation of Jiangsu Province(Nos.BK20190044,BK20210736);funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD);the China Postdoctoral Science Foundation(No.2020M681431)。

摘　　要：The hunt for agents that are suitable for actinide decorporation to reduce the whole-body load of actinide in accidental internal exposure is the ever-lasting goal in radiation protection and medical treatment in nuclear emergency.All current decorporation agents can be categorized as two groups,one is the molecular ligands,and the other is the nanoparticles decorated with molecular ligands.Here in this work,functional nanodiamonds(fN Ds)with ss DNA(the endogenous biomacromolecule rich in phosphate groups)loaded on the NDs is reported,which poses good uranyl adsorption selectivity,high cellular uptake,fast excretion,and effective decorporation of uranyl from rat renal proximal tubular epithelial cells(NRK-52E).All those results corroborate that f NDs can potentially serve as a brand new family of chelators for actinide decorporation.

关 键 词：NANODIAMOND SSDNA URANIUM DECORPORATION 

分 类 号：TQ163[化学工程—高温制品工业] TB383.1[一般工业技术—材料科学与工程]