无抽搐电休克联合重复经颅磁刺激治疗难治性抑郁症的疗效观察  

作　　者：陈倩倩[1] 徐佳婷 金美娜 许瑞智 汤义平[1] 

机构地区：[1]浙江省台州市第二人民医院,317200

出　　处：《浙江临床医学》2022年第6期890-892,共3页Zhejiang Clinical Medical Journal

基　　金：台州市科技计划项目(1902ky107)。

摘　　要：目的探讨难治性抑郁症(TRD)应用无抽搐电休克治疗(MECT)联合重复经颅磁刺激(rTMS)治疗的临床效果。方法60例TRD患者随机分为观察组和对照组,每组各30例。两组患者均给予文拉法辛胶囊抗抑郁治疗,对照组结合MECT,观察组实施MECT联合rTMS治疗。比较治疗前后两组患者的焦虑抑郁程度,以及两组的治疗有效率、治疗期间不良反应发生率。结果治疗后,观察组的HAMD-24、HAMA评分均明显降低,与对照组比较差异有统计学意义(P<0.05)。两组的治疗有效率比较,差异有统计学意义(P<0.05)。两组的不良反应发生率比较,差异无统计学意义(P>0.05)。结论MECT联合rTMS治疗TRD可显著提高临床疗效、改善患者焦虑抑郁情绪。Objective To explore the clinical effect of modified electro-convulsive therapy(MECT)combined with repeated transcranial magnetic stimulation(rTMS)in the treatment of patients with treatment-resistant depression(TRD).Methods 60 patients with TRD were randomly divided into observation group and control group,with 30 cases in each group.Both groups were given venlafaxine capsule antidepressant treatment,the control group combined with MECT,and the observation group was treated with MECT combined with rTMS.The degree of anxiety and depression,the treatment efficiency and the incidence of adverse reactions between the two groups were compared before and after treatment.Results After treatment,HAMD-24 and HAMA scores in the observation group were significantly lower than those in the control group,with statistical significance(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion MECT combined with rTMS in the treatment of TRD can significantly improve the clinical efficacy and improve the anxiety and depression of patients.

关 键 词：难治性抑郁症 无抽搐电休克治疗 重复经颅磁刺激 

分 类 号：R74[医药卫生—神经病学与精神病学]