肌层浸润性膀胱癌保留膀胱综合治疗的研究进展  

Advances in the comprehensive treatment of muscle-invasive bladder cancer with preservation of the bladder

作　　者：谭智勇 付什 栾婷[1] 黄应龙[1] 王海峰 丁明霞[1] 左毅刚[1] 王剑松[1] Tan Zhiyong;Fu Shi;Luan Ting;Huang Yinglong;Wang Haifeng;Ding Mingxia;Zuo Yigang;Wang Jiansong(Department of Urology,The Second Affiliated Hospital of Kunming Medical University,Kunming 650101,China)

机构地区：[1]昆明医科大学第二附属医院泌尿外科,昆明650101

出　　处：《中华泌尿外科杂志》2022年第6期464-468,共5页Chinese Journal of Urology

基　　金：国家自然科学基金(82060464);云南省教育厅科研基金项目(2022Y221);云南省基础研究计划青年项目(202101AU070262、202101AU070241);云南省科技厅(昆医联合专项)科技计划项目(202001AY070001-148)。

摘　　要：膀胱癌发病率居我国泌尿生殖系肿瘤第1位,是最常的泌尿系恶性肿瘤之一,其中25%~30%的患者为肌层浸润性膀胱癌,根治性膀胱切除术联合盆腔淋巴结清扫是其治疗的标准术式,能有效避免肿瘤复发或远处转移,改善患者预后。但由于手术风险高、创伤大,以及术后生活质量差等原因,部分患者不能耐受或拒绝行根治性膀胱切除术。随着对膀胱癌肿瘤异质性、生物学行为等的认识不断加深,膀胱癌治疗已从手术为主的模式转变为多学科协作的个体化综合治疗模式,保留膀胱的治疗方式可获得与根治性膀胱切除术同等的肿瘤学预后,且患者的生活质量更佳,目前已成为肿瘤治疗研究中的热点和焦点。本文就肌层浸润性膀胱癌保留膀胱综合治疗的相关研究进展进行综述。Bladder cancer(BC)ranks the first of genitourinary tumor in China and is one of the most common urological malignancies,in which 25%-30%of patients were diagnosed with muscle-invasive bladder cancer.Radical cystectomy combined with pelvic lymph node dissection is the standard procedure for treatment,which can effectively avoid tumor recurrence or distant metastasis as well as improve the prognosis of patients.However,some patients may not tolerate or refuse to undergo radical bladder surgery due to worry about high complication rate,high morbidity and poor postoperative quality of life.With the increasing understanding of bladder cancer heterogeneity and biological behavior,the treatment of bladder cancer has changed from a surgery-based treatment model to an individualized and comprehensive treatment model by multidisciplinary collaboration.The bladder-preserving treatment can achieve the same oncological prognosis as that of radical bladder surgery with a better quality of life of the patients,which has become a hot topic and focus of research in muscle-invasive bladder cancer treatment.This article reviewed the progress of research related to the comprehensive treatment of muscle-invasive bladder cancer with preservation of the bladder.

关 键 词：膀胱肿瘤 肌层浸润性膀胱癌 保留膀胱 综合治疗 

分 类 号：R737.14[医药卫生—肿瘤]