尿游离DNA在膀胱癌诊治中应用的研究进展  

Research advances of urinary cell-free DNA in the detection and therapy of bladder cancer

作　　者：李金泽 曹德宏[1] 黄引 林天海[1] 熊巧 谭大清 艾建忠 柳良仁[1] 魏强[1] Li Jinze;Cao Dehong;Huang Yin;Lin Tianhai;Xiong Qiao;Tan Daqing;Ai Jianzhong;Liu Liangren;Wei Qiang(Department of Urology,West China Hospital,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西医院泌尿外科,成都610041

出　　处：《中华泌尿外科杂志》2022年第6期469-472,共4页Chinese Journal of Urology

摘　　要：膀胱癌是泌尿系统常见的癌症,目前的诊治方法尚不令人满意。尿液中的游离DNA能够提供关于癌症的全面而重要的信息,因为它携带了来自细胞的遗传信息,这些信息直接流入尿液并从循环中运输。膀胱癌患者的尿游离DNA中携带有肿瘤疾病信息,提示其具有检测、监测以及预测膀胱癌患者的能力。尿游离DNA分析弥补了当前检测技术的不足并加强了诊断和检测能力,在转化为临床实践方面具有非常广阔的前景。本文就尿游离DNA在膀胱癌临床诊治中的应用研究作一综述。Bladder cancer is a common malignancy in the genitourinary system and the current therapeutic approaches are unsatisfactory.Urinary cell-free DNA(ucf DNA)has the ability to give comprehensive and crucial information on cancer as it carries genetic messages from cells shedding directly into urine as well as transporting from circulation.The ucf DNA of patients with bladder cancer carries disease information,suggesting that ucf DNA may have the ability to detect,monitor,and prognosticate patients with bladder cancer.The ucf DNA analysis bridges the gap between current techniques and enhances diagnostic and detection capabilities,and has a very promising future in term of translation into clinical practice.This article reviewed the progress of clinical applications of ucf DNA in bladder cancer.

关 键 词：膀胱肿瘤 膀胱癌 游离DNA 诊断 预后 生物标志物 

分 类 号：R737.14[医药卫生—肿瘤]