帕金森病与肠道菌群的相关性研究进展  

Research Progress on the Correlation between Parkinson's Disease and Intestinal Flora

作　　者：潘涛 樊慧杰 徐幸杰 李艳荣 孙芮芮 秦劭晨 贾璐 宋丽娟 王青 张波 马存根 柴智[1] PAN Tao;FAN Huijie;XU Xingjie;LI Yanrong;SUN Ruirui;QIN Shaochen;JIA Lu;SONG Lijuan;WANG Qing;ZHANG Bo;MA Cungen;CHAI Zhi(Shanxi Key Laboratory of Innovative Drug for the Treatment of Serious Diseases Basing on the Chronic Inflammation, Shanxi University of Chinese Medicine/Research Center of Neurobiology,Jinzhong 030619,China;The First Clinical College of Shanxi University of Chinese Medicine,Taiyuan 030024,China;Health Commission of Shanxi Province,Taiyuan 030006,China;Institute of Brain Science,Shanxi Datong University,Datong 037009,China)

机构地区：[1]山西中医药大学基于炎症反应的重大疾病创新药物山西省重点实验室/神经生物学研究中心,晋中030619 [2]山西中医药大学附属医院第一临床学院,太原030024 [3]山西省卫生健康委员会,太原030006 [4]山西大同大学脑科学研究所,大同037009

出　　处：《医药导报》2022年第8期1116-1120,共5页Herald of Medicine

基　　金：国家自然科学基金资助项目(81703978,81102552);中央引导地方科技发展资金自由探索类基础研究项目(YDZX20201400001483);山西省青年拔尖人才支持计划项目(晋组办字〔2019〕35号文);山西省自然科学基金项目(201901D111334);山西省留学回国人员科技活动项目择优资助项目(20200026);山西省省筹资金资助回国留学人员科研项目(2021-142);山西省“四个一批”科技兴医创新计划医学科技领军人才项目(2020RC05);山西省晋中市科技重点研发计划(社会发展)项目(Y213004);山西省高等学校科技创新计划项目(2019L0724);山西中医药大学青年科学家培育计划项目(2021PY-QN-03)。

摘　　要：肠道菌群在人体内数量庞大,对机体的生理活动具有重要的调节作用。微生物-肠-脑轴在帕金森病的发病及病程进展中起重要作用。病理性α-突触核蛋白可能起源于肠道,而肠道菌群失调影响帕金森的病程进展与帕金森病的症状严重程度。近年来,帕金森病和肠道菌群之间的关联性成为研究的热点。该文围绕肠道菌群与帕金森病的关系以及目前通过调节肠道菌群治疗帕金森病的方式进行综述,以期为帕金森病的临床诊断和治疗提供新的依据。Many intestinal florae regulate the body's physiological activities in the human intestine.Microbiota-gut-brain axis plays an important role in the pathogenesis and the progression of Parkinson's disease(PD).Pathologicalα-synuclein may originate in the intestine,while the alteration of intestinal flora affects the course progression and the symptom severity of PD.Recently,the association between PD and gut microbiota has been a hot subject of intense interest.This paper reviews the relationship between PD and gut microbiota and the current treatment of PD by regulating gut microbiota to offer a new basis for the diagnosis and treatment of PD.

关 键 词：帕金森病 肠道菌群 微生物-肠-脑轴 Α-突触核蛋白 

分 类 号：R742.5[医药卫生—神经病学与精神病学] R975[医药卫生—临床医学]