中医熏蒸联合依达拉奉治疗脑卒中临床研究  

Clinical Study on Chinese Medicine Fumigation Combined with Edaravone for Stroke

作　　者：廖庆红[1] 支建峰 徐文文[1] 何宇波[1] 诸丹维 LIAO Qinghong;ZHI Jianfeng;XU Wenwen;HE Yubo;ZHU Danwei

机构地区：[1]嘉善县第一人民医院康复医学科,浙江嘉善314100

出　　处：《新中医》2022年第13期41-44,共4页New Chinese Medicine

基　　金：浙江省医药卫生科研项目(2021ZH048);浙江省医院可持续发展扬子江研究项目(2020ZHA-YZJ104)。

摘　　要：目的:观察中医熏蒸联合依达拉奉治疗脑卒中临床疗效及对炎性因子的影响。方法:选取2019年4月—2021年4月嘉善县第一人民医院收治的脑卒中患者150例,随机分为对照组及试验组各75例。对照组采用依达拉奉治疗,试验组在对照组基础上联用中医熏蒸治疗。比较2组临床疗效及治疗前后中医证候积分、神经功能缺损、神经元损伤指标及炎性因子。结果:治疗后,试验组总有效率高于对照组(P<0.05)。治疗后,2组中医证候积分、美国国立卫生院卒中量表(NIHSS)评分均较治疗前降低,且试验组降低幅度高于对照组(P<0.05)。治疗后,2组胰岛素样生长因子-1(IGF-1)较治疗前升高,神经元特异性烯醇化酶(NSE)、高敏C-反应蛋白(hs-CRP)、脂蛋白相关磷脂酶A2(Lp-PLA2)、肿瘤坏死因子-α(TNF-α)、正五聚蛋白3(PTX3)、白细胞介素-10(IL-10)较治疗前降低(P<0.05),且试验组上述指标改善优于对照组(P<0.05)。结论:中医熏蒸联合依达拉奉治疗脑卒中患者临床疗效较好,可有效改善患者神经功能缺损,降低炎性反应。Objective:To observe the clinical effect of the therapy of Chinese medicine fumigation combined with edaravone for stroke and its effect on inflammatory factors.Methods:A total of 150 patients with stroke who were admitted to the First People's Hospital of Jiashan from April 2019 to April 2021 were randomly divided into the control group and the experiment group,with 75 cases in each group.The control group was treated with edaravone,and the experiment group was additionally treated with Chinese medicine fumigati on based on the treatment of the control group.The clinical effects and Chinese medicine syndrome scores,defects of neurological function,indexes of neuron injury and inflammatory factors before and after treatment were compared between the two groups.Results:After treatment,the total effective rate in the experiment group was higher than that in the control group(P<0.05).After treatment,the scores of Chinese medicine syndrome and National Institutes of Health Stroke Scale(NIHSS)in the two groups were decreased when compared with those before treatment,and the decreases in the experiment group were larger than those in the control group(P<0.05).After treatment,the levels of insulin-like growth factor-1(IGF-1)in the two groups were increased when compared with those before treatment,and the levels of neuron-specific enolase(NSE),high-sensitivity C-reactive protein(hs-CRP),lipoproteinassociated phospholipase A2(Lp-PLA2),tumor necrosis factor-α(TNF-α),pentraxin 3(PTX3)and interleukin-10(IL-10)were decreased(P<0.05),and the improvement effect of the above indexes in the experiment group was better than that in the control group(P<0.05).Conclusion:The therapy of Chinese medicine fumigation combined with edaravone has a good clinical effect on patients with stroke,which can effectively improve the defects of neurological function and reduce the inflammatory responses.

关 键 词：脑卒中 中医熏蒸 依达拉奉 神经元特异性烯醇化酶 肿瘤坏死因子 胰岛素样生长因子-1 

分 类 号：R743[医药卫生—神经病学与精神病学]