敞开式离子化质谱技术在中药材及中药饮片质量评价中的应用进展  

Application Progress in Quality Evaluation of Chinese Medicinal Materials and Chinese Medicine Decoction Pieces based on Ambient Ionization Mass Spectrometry

作　　者：黄文静 叶楚璇[1,3] 徐浩然 黄志伟 王登辉 王乐琪 李莎莎 严诗楷 肖雪 HUANG Wen-jing;YE Chu-xuan;XU Hao-ran;HUANG Zhi-wei;WANG Deng-hui;WANG Le-qi;LI Sha-sha;YAN Shi-kai;XIAO Xue(Guangdong Metabolic Disease Research Center of Integrated Chinese and Western Medicine,School of Traditional Chinese Medicine,Institute of Traditional Chinese Medicine,Guangdong Pharmaceutical University,Guangzhou 510006,China;NMPA Key Laboratory for Rapid Testing Technology of Drugs,Guangdong Institute for Drug Control,Guangzhou 510663,China;The Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510120,China;School of Pharmacy,Shanghai Jiao Tong University,Shanghai 200240,China)

机构地区：[1]广东药科大学中医药研究院中药学院广东省代谢病中西医结合研究中心,广东广州510006 [2]国家药品监督管理局药品快速检验技术重点实验室(广东省药品检验所),广东广州510663 [3]广州中医药大学第二附属医院,广东广州510120 [4]上海交通大学药学院,上海200240

出　　处：《化学试剂》2022年第8期1079-1087,共9页Chemical Reagents

基　　金：国家自然科学基金资助项目(81830117,81603070);国家药品监督管理局快速检验技术重点实验室开放项目(KF2022002,KF2022006);广东省农业农村厅省级乡村振兴战略专项农业科技创新及推广体系建设项目(2020KJ265);中医药防治自身免疫疾病重庆市重点实验室开放项目(ZDSYS-KF-2021-1)。

摘　　要：中药材及中药饮片是中药产业链的重要组成部分,其质量是保障中成药质量和稳定发挥临床疗效的基础。为了实现中药材及中药饮片质量更高效的控制与监管,新技术、新设备、新方法不断产生。敞开式离子化质谱技术是近些年迅速发展起来的一种新型检测技术,具有实时、直接、准确、快速的特有优点,在中药分析、质量分析与质量控制领域的应用越来越多,取得了良好的应用效果。归纳梳理了敞开式离子化质谱技术的基本原理、特点,及其在中药材及中药饮片质量分析与评价中的应用现状,总结该技术在中药材及中药饮片质量评价中所面临的问题,并对其未来发展方向进行展望。Chinese medicinal materials and Chinese medicinal decoction pieces are the important parts of the Chinese medicine industry chain,and the quality is the basis of guaranteeing the quality of Chinese patent medicine and developing its clinical efficacy stably.To effectively supervise the quality of Chinese medicinal materials and decoction pieces,new techniques,advanced instruments and new methods for quality control have been developed.Ambient ionization mass spectrometry(AIMS)is a new detection technology developed rapidly in recent years.AIMS has the unique advantages of being real-time,direct,accurate,and fast.In recent years,AIMS has been applied in this field.The basic principle,characteristics,and application progress of AIMS in quality evaluation of Chinese herbal decoction pieces were summarized,the problems faced by this technology in quality evaluation of Chinese herbal decoction pieces were summarized and the future development direction of this technology has prospected.

关 键 词：敞开式离子化 质谱 中药材 中药饮片 质量控制 

分 类 号：R917[医药卫生—药物分析学]