Recent Progress on Highly Selective and Sensitive Electrochemical Aptamer-based Sensors  

作　　者：TANG Tianwei LIU Yinghuan JIANG Ying 

机构地区：[1]College of Chemistry,Beijing Normal University,Beijing 100875,P.R.China [2]Beijing National Laboratory for Molecular Sciences,Beijing 100190,P.R.China

出　　处：《Chemical Research in Chinese Universities》2022年第4期866-878,共13页高等学校化学研究（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.22104006);the Beijing Nova Program of Science and Technology,China(No.Z191100001119108);the Fund of Beijing National Laboratory for Molecular Sciences,China(No.BNLMS202009).

摘　　要：Highly selective,sensitive,and stable biosensors are essential for the molecular level understanding of many physiological activities and diseases.Electrochemical aptamer-based(E-AB)sensor is an appealing platform for measurement in biological system,attributing to the combined advantages of high selectivity of the aptamer and high sensitivity of electrochemical analysis.This review summarizes the latest development of E-AB sensors,focuses on the modification strategies used in the fabrication of sensors and the sensing strategies for analytes of different sizes in biological system,and then looks forward to the challenges and prospects of the future development of electrochemical aptamerbased sensors.

关 键 词：Electrochemical biosensor APTAMER Biomolecular recognition Biological system 

分 类 号：TP212[自动化与计算机技术—检测技术与自动化装置]