血清α-1抗胰蛋白酶与青年急性缺血性脑卒中患者病情严重程度和短期预后的相关性  

Association of serumα-1 antitrypsin with disease severity and short-term prognosis in young patients with acute ischemic stroke

作　　者：郭留芹[1] Guo Liuqin(Department of Neurology,Anyang People's Hospital,Anyang 455000,China)

机构地区：[1]河南省安阳市人民医院神经内科,455000

出　　处：《临床医学》2022年第5期8-11,共4页Clinical Medicine

摘　　要：目的探讨血清α-1抗胰蛋白酶与青年急性缺血性脑卒中患者病情严重程度和短期预后的相关性。方法选取安阳市人民医院2008年4月至2021年1月神经内科收治的60名首次青年急性缺血性脑卒中(AIS)患者为病例组,选择同期本院健康体检者76例为正常对照组。病例组患者在入院时按照美国国立卫生研究院卒中量表(NIHSS)评分分为轻度组20例,中度组30例,重度组10例。按照发病至手术时间的不同分为<24 h组32例,≥24 h且≤72 h组18例,>72 h组10例。所有参与者均在入院时测定血清α-1抗胰蛋白酶水平。比较不同组研究对象血清α-1抗胰蛋白酶水平,采用多因素Logistic回归分析探讨预后的影响因素。结果病例组血清α-1抗胰蛋白酶水平高于正常对照组(P<0.05)。随着疾病严重程度增加,血清α-1抗胰蛋白酶水平逐渐升高(P<0.05)。随着发病至手术时间段延长,青年AIS患者血清α-1抗胰蛋白酶水平逐渐升高(P<0.05)。预后不良组血清α-1抗胰蛋白酶、IL-4、IL-8、IL-12、TNF-α、hs-CRP水平高于预后良好组,IFN-γ水平低于预后良好组(P<0.05)。Logistic回归分析显示,高水平α-1抗胰蛋白酶、疾病越严重、发病至治疗时间越长是青年AIS患者预后不良的危险因素(P<0.05)。结论青年AIS患者血清α-1抗胰蛋白酶水平升高,且与患者病情严重程度和短期预后相关,高水平α-1抗胰蛋白酶为青年AIS患者预后不良的危险因素。Objective To investigate the relationship between serumα-1 antitrypsin and the severity and short-term prognosis of young patients with acute ischemic stroke.Methods Sixty first-time young patients with acute ischemic stroke(AIS)treated in the Department of Neurology of Anyang People’s Hospital from April 2008 to January 2021 were selected as the case group,and 76 cases of physical examination in Anyang People’s Hospital in the same period were selected as the normal control group.The patients in the case group were divided into mild group(20 cases),moderate group(30 cases)and severe group(10 cases)according to the National Institutes of Health Stroke Scale(NIHSS).According to the time from onset to operation,the patients were divided into<24 h group(n=32),≥24 h and≤72 h group(n=18)and>72 h group(n=10).Serum alpha-1 antitrypsin levels were measured at admission for all participants.The serumα-1 antitrypsin levels of subjects in different groups were compared,and multivariate Logistic regression analysis was used to explore the prognostic factors.Results The serumα-1 antitrypsin level in case group was higher than that in control group(P<0.05).With the increase of disease severity,serumα-1 antitrypsin level increased gradually(P<0.05).With the extension of time from onset to operation,serumα-1 antitrypsin level in young AIS patients gradually increased(P<0.05).The serum levels ofα-1 antitrypsin,IL-4,IL-8,IL-12,TNF-αand hs-CRP in the poor prognosis group were higher than those in the normal control group,and the levels of IFN-γwere lower than those in the good prognosis group(P<0.05).Logistic regression analysis showed that high level ofα-1 antitrypsin,more serious disease and longer time from onset to treatment were risk factors for poor prognosis in young AIS patients(P<0.05).Conclusions Serumα-1 antitrypsin level is increased in young AIS patients,which is associated with the severity of the disease and short-term prognosis.Highα-1 antitrypsin level is a risk factor for poor prognosis in young

关 键 词：血清α-1抗胰蛋白酶 青年 急性缺血性脑卒中 短期预后 

分 类 号：R743.3[医药卫生—神经病学与精神病学]