3D-CTBA导航的解剖性肺段切除术对非小细胞肺癌患者肺功能及血清TGF-α、VEGF、IL-1Ra水平的影响  

Effect of 3D-CTBA guided anatomical segmentectomy on lung function and serum TGF-α,VEGF,IL-1Ra levels in patients with non-small cell lung caner

作　　者：姜功前[1] 宋静超[1] 王国磊[1] 汤少鹏[1] 丁成智[1] Jiang Gongqian;Song Jingchao;Wang Guolei;Tang Shaopeng;Ding Chengzhi(Department of Thoracic Surgery,Henan Provincial Chest Hospital,Zhengzhou 450003,China)

机构地区：[1]河南省胸科医院胸外科,郑州450003

出　　处：《中国实用医刊》2022年第9期1-4,共4页Chinese Journal of Practical Medicine

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20190739)。

摘　　要：目的研究三维CT支气管血管成像(3D-CTBA)导航的解剖性肺段切除术对非小细胞肺癌(NSCLC)患者肺功能及血清转化生长因子-α(TGF-α)、血管内皮生长因子(VEGF)、白细胞介素1受体拮抗剂(IL-1Ra)的影响。方法回顾性收集2018年6月至2020年12月河南省胸科医院收治的100例非小细胞肺癌患者作为研究对象,以手术方式将患者分为观察组(52例)和对照组(48例)。观察组于3D-CTBA导航下行解剖性肺段切除术,对照组采用胸腔镜肺叶切除术。比较两组的切口长度、出血量、手术时间、住院时间、引流天数等手术指标;比较两组血清TGF-α、VEGF、IL-1Ra水平;比较两组肺功能及并发症发生情况。结果观察组出血量[(115.56±46.87)ml]、手术时间[(136.89±26.97)min]、住院时间[(7.68±2.68)d]、引流时间[(3.16±0.86)d]均少于对照组[(176.87±51.36)ml、(102.78±21.68)min、(9.98±3.16)d、(4.39±1.14)d],P均<0.05;两组淋巴结清扫个数比较差异未见统计学意义(P>0.05)。治疗后,两组第1秒用力呼出量、用力肺活量、最大通气量比较差异均有统计学意义(P均<0.05)。观察组血清TGF-α[(9.58±1.29)pg/ml]、VEGF[(112.68±8.14)pg/ml]、IL-1Ra[(336.87±68.49)pg/ml]水平低于对照组[(13.68±1.87)、(146.68±10.37)、(458.34±102.67)pg/ml],P均<0.05。观察组并发症发生率(1.9%,1/52)低于对照组(12.5%,6/48),P<0.05。结论应用CTBA导航的解剖性肺段切除术治疗NSCLC效果显著,可以更好保留患者肺组织,提升术后肺功能,手术创伤较小且并发症较少。Objective To study the effect of 3 dimensional computed tomography bronchial angiography(3D-CTBA)guided anatomical segmentectomy on lung function and serum transforming growth factor-α(TGF-α),vascular endothelial growth factor(VEGF),interleukin-1 receptor antagonist(IL-1Ra)in patients with non-small cell lung cancer(NSCLC).Methods One hundred patients with NSCLC treated in Henan Provincial Chest Hospital from June 2018 to December 2020 were retrospectively collected as the research objects.The patients were divided into observation group(52 cases)and control group(48 cases)according to the surgical methods.The observation group underwent 3D-CTBA guided anatomical segmentectomy,and the control group was treated by thoracoscopic lobectomy.The incision length,blood loss,operation time,hospital stay,drainage days were compared between the two groups.The serum TGF-α,VEGF,and IL-1Ra levels were compared between the two groups;pulmonary function and complications were compared between the two groups.Results The blood loss,operation time,hospital stay,and drainage days in the observation group were(115.56±46.87)ml,(136.89±26.97)min,(7.68±2.68)d,and(3.16±0.86)d,respectively,less than the(176.87±51.36)ml,(102.78±21.68)min,(9.98±3.16)d,and(4.39±1.14)d in the control group(all P<0.05);however,there was no significant difference in the number of lymph node dissections between the two groups(P>0.05).After treatment,there were significant differences in forced expiratory volume in one second,forced vital capacity,and maximum ventilation volume between the two groups(all P<0.05).The levels of TGF-α,VEGF and IL-1Ra of the observation group were(9.58±1.29)pg/ml,(112.68±8.14)pg/ml,and(336.87±68.49)pg/ml,respectively,which were lower than the(13.68±1.87)pg/ml,(146.68±10.37)pg/ml,and(458.34±102.67)pg/ml of the control group(all P<0.05).The incidence of complications in the observation group(1.9%,1/52)was lower than that in the control group(12.5%,6/48),P<0.05.Conclusions CTBA guided anatomical segmentectomy for the

关 键 词：非小细胞肺癌 三维CT支气管血管成像导航 解剖性肺段切除]术 肺功能 转化生长因子-Α 血管内皮生长因子 白细胞介素1受体拮抗剂 

分 类 号：R734.2[医药卫生—肿瘤]