经乳晕腔镜根治术对甲状腺癌患者吞咽功能及血清VEGF、Tg水平的影响  

Effects of laparoscopic radical mastectomy via breast areola approach on swallowing function and serum VEGF and Tg levels in patients with thyroid cancer

作　　者：柏建民 郭俊吉 Bai Jianmin;Guo Junji(Department of General Surgery,Linfen People’s Hospital,Linfen 041000,China;Department of SurgeryⅢ,People’s Hospital of Yaodu District,Linfen 041000,China)

机构地区：[1]临汾市人民医院普外科,临汾041000 [2]临汾市尧都区人民医院外三科,临汾041000

出　　处：《中国实用医刊》2022年第9期33-36,共4页Chinese Journal of Practical Medicine

摘　　要：目的探究经乳晕腔镜根治术对甲状腺癌患者吞咽功能及血清血管内皮生长因子(VEGF)、甲状腺球蛋白(Tg)的影响。方法抽取2017年2月至2020年12月于临汾市人民医院就诊的甲状腺癌患者60例,按随机数字表法分为观察组和对照组,每组30例。对照组采用常规甲状腺癌根治术治疗,观察组采用经乳晕腔镜根治术治疗,术后两组均随访1个月。比较两组甲状腺癌患者手术情况,术后1~3 d疼痛程度,术后1周、1个月嗓音和吞咽障碍发生情况,术前及术后1 d血清VEGF、Tg水平。结果与对照组比较,观察组手术时间较长,拔管及住院时间均较短,且术中出血量较少(P均<0.05)。术后1~3 d,两组疼痛评分均呈下降趋势,且观察组低于对照组(P<0.05)。术后1周,观察组嗓音障碍发生率为3.33%(1/30),低于对照组的20.00%(6/30),P<0.05;观察组无吞咽障碍,对照组吞咽障碍发生率为16.67%(5/30),P<0.05。术后1个月,两组均无吞咽障碍,观察组无嗓音障碍,对照组嗓音障碍发生率为3.33%(1/30),P>0.05。术后1 d,两组血清VEGF、Tg水平均低于术前,且观察组低于照组(P<0.05)。结论经乳晕腔镜根治术能够有效缩短甲状腺癌患者恢复时间并减少术中出血,缓解患者术后疼痛程度,降低术后嗓音及吞咽障碍的发生率,还可抑制新血管形成和癌细胞生长。Objective To investigate the effect of laparoscopic radical mastectomy via breast areola approach on swallowing function and levels of serum vascular endothelial growth factor(VEGF)and thyroglobulin(Tg)in patients with thyroid cancer.Methods Sixty patients with thyroid cancer treated in Linfen People’s Hospital from February 2017 to December 2020 were selected,and they were divided into observation group and control group by random number table method,with 30 cases in each group.The control group was treated by conventional radical thyroidectomy,and the observation group was treated by laparoscopic radical mastectomy via breast areola approach.Both groups were followed up for 1 month after operation.The operation conditions,1-and 3-day postoperative pain degree,occurrence of voice and swallowing disorders 1 week and 1 month after operation,and the levels of serum VEGF and Tg before and 1 day after operation were compared between the two groups.Results Compared with the control group,the observation group had longer operation time,shorter extubation and hospitalization time,and less intraoperative blood loss(all P<0.05).The pain scores of both groups showed a downward trend 1-3 days after operation,and the pain scores of the observation group was lower than that of the control group(P<0.05).One week after operation,the incidence of voice disorder in the observation group was 3.33%(1/30),which was lower than 20.00%(6/30)in the control group(P<0.05);there was no dysphagia in the observation group,and the incidence of dysphagia in the control group was 16.67%(5/30)1 week after operation(P<0.05).One month after operation,there was no dysphagia in the two groups,no voice disorder in the observation group,and the incidence of voice disorder in the control group was 3.33%(1/30),P>0.05.One day after operation,the levels of serum VEGF and Tg in the two groups were lower than those before operation,and levels of VEGF and Tg in the observation group were lower than those in the control group(P<0.05).Conclusions Laparoscopi

关 键 词：甲状腺癌 经乳晕腔镜根治术 血管内皮生长因子 嗓音障碍 吞咽障碍 

分 类 号：R736.1[医药卫生—肿瘤]