外伤性感染性眼内炎患者脱盲因素研究  

Study on factors in patients to get rid of blindness with post traumatic infectious endophthalmitis

作　　者：唐秋阳 施健[1] 张俊芳[1] 张淑丹 桑爱民[1] 石海红[1] Qiu-Yang Tang;Jian Shi;Jun-Fang Zhang;Shu-Dan Zhang;Ai-Min Sang;Hai-Hong Shi(Department of Ophthalmology,the Affiliated Hospital of Nantong University,Nantong 226001,Jiangsu Province,China)

机构地区：[1]南通大学附属医院眼科,江苏省南通市226001

出　　处：《国际眼科杂志》2022年第8期1402-1406,共5页International Eye Science

基　　金：南通市科技项目(No.MS12020033)。

摘　　要：目的:探讨影响外伤性感染性眼内炎(PTIE)患者脱盲的因素。方法:回顾性分析2010-01/2020-12在南通大学附属医院眼科就诊的PTIE患者169例169眼临床资料。患者接受玻璃体腔注射抗生素(IVIA)和/或玻璃体切除术(PPV)治疗后,末次随访最佳矫正视力(BCVA)≥0.05为脱盲组(103眼)和BCVA<0.05为单眼盲组(66眼),分析影响患者脱盲的因素。结果:PTIE患者治疗后脱盲率为53.5%。单因素分析显示治疗前BCVA≥手动、不伴有视网膜脱离、眼内炎眼底分级<3级以及未培养出毒力强微生物是患者脱盲的有利因素(P<0.05);多因素Logistic分析显示治疗前BCVA分两组,BCVA≥手动(OR=0.253, 95%CI:0.108~0.592)以及不伴有视网膜脱离(OR=0.241, 95%CI:0.103~0.564)是患者脱盲的有利因素。结论:治疗前BCVA较好、不伴有视网膜脱离、眼内炎眼底分级<3级以及未感染毒力强微生物是PTIE患者最终脱盲的有利因素。AIM:To investigate the factors affecting patients with post traumatic infectious endophthalmitis(PTIE) relieving from blindness.METHODS: A retrospective study was conducted on 169 patients(169 eyes) with PTIE from January 2010 to December 2020 in the department of ophthalmology, the Affiliated Hospital of Nantong University. After treatment of intravitreal injection of antibiotics(IVIA) and/or pars plana vitrectomy(PPV), the patients were divided into the getting rid of blindness group(103 eyes) and unilateral blindness group(66 eyes) according to the last follow-up of best correct visual acuity(BCVA) ≥0.05. The factors affecting the patients to get rid of blindness were analyzed.RESULTS: The rate of relieving from blindness was 53.5%. Univariate analysis showed that BCVA before treatment ≥ hand movement, no retinal detachment, fundus grade of endophthalmitis < grade 3 and no strong virulence of infected microorganisms were beneficial for patients to get rid of blindness(P<0.05). Multivariate Logistic regression analysis identified that BCVA before treatment ≥ hand movement(OR=0.253, 95%CI: 0.108-0.592) and no retinal detachment(OR=0.241, 95%CI: 0.103-0.564) were favorable factors for patient to get rid of blindness.CONCLUSION: Better BCVA before treatment, no retinal detachment, endophthalmitis fundus grade < 3, and no strong virulence of infected microorganisms are favorable factors for patients with PTIE to get rid of blindness finally.

关 键 词：眼内炎 开放性眼外伤 盲 预后 

分 类 号：R779.1[医药卫生—眼科]