多烯磷脂酰胆碱联合还原型谷胱甘肽对酒精性肝病患者肝功能的影响  

Effect of Polyene Phosphatidylcholine Combined with Reduced Glutathione on Liver Function in Patients with Alcoholic Liver Disease

作　　者：于杰 YU Jie(Shenyang 739 Hospital,Shenyang110034,China)

机构地区：[1]沈阳七三九医院,辽宁沈阳110034

出　　处：《中国医药指南》2022年第21期57-60,共4页Guide of China Medicine

摘　　要：目的分析酒精性肝病患者肝功能患者采用多烯磷脂酰胆碱联合还原型谷胱甘肽对其肝功能的影响。方法本次研究的主体为我院收治的80例酒精性肝病患者,选取时间段为2018年9月至2019年9月,随机将患者分为人数均为40例的两组,一组为对照组(40例)、另一组为观察组(40例);将多烯磷脂酰胆碱治疗法应用于对照组,观察组在对照组的基础上采用还原型谷胱甘肽治疗,对两组患者临床疗效进行比较。结果与对照组相比,观察组患者天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)、γ-谷氨酰转肽酶(γ-GT)及总胆红素(TBil)水平均更低,差异显著(P<0.05);相比于对照组,观察组的治疗总有效率更高,差异显著(P<0.05)。两组患者不良反应发生率的比较:观察组患者不良反应发生率4例(10.00%)低于对照组9例(22.50%),差异显著(P<0.05)。两组患者治疗前后肝纤维化各项指标比较:治疗前,两组患者肝纤维化各项指标比较之间均无显著差异;治疗后观察组透明质酸、层黏蛋白、Ⅲ型前胶原肽三项指标水平分别为(146.43±24.36)μg/L、(136.52±16.11)μg/L、(133.52±14.25)μg/L,均低于对照组(P<0.05)。结论与单纯采用多烯磷脂酰胆碱治疗法相比,对酒精性肝病患者采取多烯磷脂酰胆碱联合还原型谷胱甘肽治疗能取得良好效果,尤其体现在肝功能指标的改善,不良反应发生率的降低,安全性的提高等方面,其具有的优势值得推广使用。Objective To analyze the effect of polyene phosphatidylcholine combined with Reduced Glutathione on liver function in patients with alcoholic liver disease.Methods Eighty patients with alcoholic liver disease in our hospital were randomly divided into two groups of 40 patients from September 2018 to September 2019,one group was the control group(40 cases),the other group was the observation group(40 cases).The polyene phosphatidylcholine therapy was used in the control group.The observation group was treated with reduced glutathione therapy on the basis of the control group,the clinical curative effect of the two groups was compared.Results Compared with the control group,the levels of AST,ALT,γ-GT and TBil in the observation group were significantly lower than those in the control group(P<0.05),the total effective rate of the observation group was higher,the difference was significant(P<0.05).Comparison of the incidence of adverse reactions between the two groups of patients the incidence:adverse reactions in 4 cases(10.00%)of the observation group was lower than that of 9 cases(22.50%)in the control group,and the difference was significant(P<0.05).Comparison of liver fibrosis indicators between the two groups of patients before and after treatment:before treatment,there was no significant difference between the two groups patients liver fibrosis indicators;after treatment,the observation group had hyaluronic acid,laminin,and typeⅢprocollagen levels were(146.43±24.36)μg/L,(136.52±16.11)μg/L,and(133.52±14.25)μg/L,all lower than the control group(P<0.05).Conclusion Compared with polyene phosphatidylcholine alone,polyene phosphatidylcholine combined with reduced glutathione can achieve good results in patients with alcoholic liver disease,especially in the improvement of liver function indexes,the reduction of the incidence of adverse reactions,the improvement of safety and other aspects,its advantages are worth promoting the use.

关 键 词：多烯磷脂酰胆碱 还原型谷胱甘肽 酒精性肝病患者 肝功能 

分 类 号：R575[医药卫生—消化系统]