持续血液滤过联合生长抑素治疗重症急性胰腺炎的应用  

Application of Continuous Hematofiltration Combined with Somatostatin for the Treatment of Severe Acute Pancreatitis

作　　者：程小梅 CHENG Xiaomei(Zhangzhou Affiliated Hospital of Fujian Medical University,Zhangzhou 363000,China)

机构地区：[1]福建医科大学附属漳州市医院,福建漳州363000

出　　处：《中国医药指南》2022年第21期65-67,71,共4页Guide of China Medicine

摘　　要：目的研究持续血液滤过和生长抑素联合用于重症急性胰腺炎的价值。方法选取符合要求的患者作为研究对象,一共选取96例,要求所有患者均在2018年10月至2021年9月期间在我院接受治疗,并且符合重症急性胰腺炎的诊断标准,将患者均分为两组并且使用不同的方式进行治疗。研究组采取持续血液滤过和生长抑素联合疗法,对照组行持续血液滤过治疗。对比两组患者治疗之后在不良反应发生率、肠黏膜功能、临床症状改善时间、血清生化指标及临床疗效的临床数据差异。结果针对恶心呕吐出现的时间、腹胀缓解时间和腹痛消失时间,研究组比对照组短(P<0.05)。对于住院时间这项指标,研究组(18.63±3.14)d,和对照组(25.47±3.96)d比较更短(P<0.05)。针对者胃肠道功能评分以及白细胞(WBC)、淀粉酶(AMY)、白细胞介素-6(IL-6),与对照组相比,研究组患者上述指标均更低(P<0.05)。研究组总有效率97.92%,比对照组(81.25%)高(P<0.05)。对于不良反应发生率,两组患者之间的临床差异在统计学方面无差异(P>0.05)。结论于重症急性胰腺炎患者的治疗中联用持续血液滤过和生长抑素,可迅速缓解症状,对炎性指标有明显的降低作用,疗效提升更为明显,且住院时间也更短。Objective To study the value of continuous hemofiltration combined with somatostatin in severe acute pancreatitis.Methods A total of 96 patients were selected as the study subjects.All patients were required to receive treatment in our hospital from October 2018 to September 2021,and all patients met the diagnostic criteria of severe acute pancreatitis.Patients were divided into two groups and treated in different ways.The study group received continuous hemofiltration and somatostatin combined therapy,and the control group received continuous hemofiltration therapy.The clinical data of the two groups were compared in the incidence of adverse reactions,intestinal mucosal function,improvement time of clinical symptoms,serum biochemical indicators and clinical efficacy after treatment.Results In terms of the occurrence time of nausea and vomiting,the relief time of abdominal distention and the disappearance time of abdominal pain,the study group was shorter than the control group(P<0.05).The length of hospital stay was shorter in the study group(18.63±3.14)days than in the control group(25.47±3.96)days(P<0.05).Compared with the control group,the gastrointestinal function scores,white blood cells(WBC),amylase(AMY),and interleukin-6(IL-6)of the subjects in the study group were all lower(P<0.05).The total effective rate of the study group was 97.92%higher than that of the control group(81.25%,P<0.05).There was no statistical difference in the incidence of adverse reactions between two groups(P>0.05).Conclusion The combination of continuous hemofiltration and somatostatin in the treatment of patients with severe acute pancreatitis can quickly relieve symptoms,significantly reduce inflammatory indicators,improve the efficacy more significantly,and shorten the hospital stay.

关 键 词：急性胰腺炎 血液滤过 疗效 生长抑素 

分 类 号：R576[医药卫生—消化系统]