氯氮平联合利培酮治疗阴性症状为主精神分裂症患者的临床效果  

Clinical Effect of Clozapine Combined with Risperidone in the Treatment of Schizophrenia with Negative Symptoms

作　　者：王锦 WANG Jin(Shenyang Mental Health Center,Shenyang 110000,China)

机构地区：[1]沈阳市精神卫生中心,辽宁沈阳110000

出　　处：《中国医药指南》2022年第20期88-90,共3页Guide of China Medicine

摘　　要：目的分析在精神分裂症(阴性症状)治疗中开展氯氮平与利培酮联合治疗方案的临床效果。方法分析对象为2019年1月至2020年1月在我院就诊的精神分裂症(阴性症状)患者88例,采用双色球抽签法实施分组,44例选择氯氮平与利培酮联合治疗方案的患者纳入试验组,44例选择利培酮治疗方案的患者纳入对照组,对2种治疗方案开展的效果进行对比和评价。结果与单药治疗方案治疗有效率(84.09%)相比,联合药物治疗方案所得总治疗有效率(97.73%)提升明显,对比数据差异有统计学意义(χ^(2)=4.9500,P<0.05);在治疗方案开展前,两组患者PANSS总分、阴性症状评分、阳性症状评分对比,数据差异无统计学意义(t=0.0776、0.0098、0.0150,P>0.05);在治疗方案开展后,两组PANSS总分、阴性症状评分、阳性症状评分均得以降低明显,与对照组单药治疗方案相比,试验组联合用药治疗方案开展后,PANSS总分(46.33±8.19)分、阴性症状评分(11.23±4.26)分、阳性症状评分(25.18±8.20)分降低明显,对比数据差异有统计学意义(t=9.3106、4.0422、3.1097,P<0.05)。在治疗方案开展前,两组患者眼区情绪识别功能评分对比,数据差异无统计学意义(t=0.3302,P>0.05);在治疗方案开展后,与对照组患者(16.08±3.08)分相比,试验组患者眼区情绪识别功能评分(22.36±2.10)分提升明显,对比数据差异有统计学意义(t=11.1746,P<0.05);与对照组(15.91%)相比,试验组不良反应发生率(2.27%)降低明显,对比数据差异有统计学意义(χ^(2)=4.9500,P<0.05)。结论在精神分裂症(阴性症状)患者的治疗中开展氯氮平与利培酮联合治疗方案可达到令人满意的疗效。Objective To analyze the clinical effect of clozapine combined with risperidone in the treatment of schizophrenia(negative symptoms).Methods From January 2019 to January 2020m88 schizophrenic patients(negative symptoms)who were treated in our hospital were selected for analysis.They were divided into two groups by the method of dichroic balloting,44 patients who chose the combination of clozapine and risperidone were included in the experimental group,44 patients who chose risperidone were included in the control group.The effects of the two treatment schemes were compared and evaluated.Results Compared with the treatment effective rate of the single-drug treatment program(84.09%),the total treatment effective rate(97.73%)obtained from the combined drug treatment program is significantly improved,and the comparative data is significantly different(χ^(2)=4.9500,P<0.05).Before the treatment program is launched The difference between the two groups of patients’PANSS total scores,negative symptom scores,and positive symptom scores was not significant(t=0.0776,0.0098,0.0150,P>0.05);after the treatment plan was carried out,the two groups of PANSS total scores,negative symptoms scores and the scores of positive symptoms were significantly reduce,compared with the single-drug treatment program of the control group,after the combined drug treatment program of the experimental group was carried out,the total score of PANSS(46.33±8.19)and the score of negative symptoms(11.23±4.26)were obtained,the positive symptom score(25.18±8.20)was significantly reduced,and the comparison data was significantly different(t=9.3106,4.0422,3.1097,P<0.05).Before the two treatment options were carried out,the comparison data of the eye area emotion recognition function scores of the two groups of patients was not obvious(t=0.3302,P>0.05);after the treatment,compared with the control group(16.08±3.08),the experimental group’s eye emotion recognition score was(22.36±2.10),the improvement is obvious,and the comparison data is significa

关 键 词：精神分裂症 阴性症状 氯氮平 利培酮 

分 类 号：R749.3[医药卫生—神经病学与精神病学]