不可逆电穿孔技术在肝癌消融治疗中的应用  

Application of irreversible electroporation in the ablation treatment of liver cancer

作　　者：许敏[1] 许丹霞 蒋天安[1] XU Min;XU Danxia;JIANG Tian’an(Department of Ultrasound Medicine,First Affiliated Hospital,School of Medicine,Zhejiang University,Zhejiang Provincial Key Laboratory of Pulsed Electric Field Technology for Medical Transformation,Hangzhou,Zhejiang Province 310006,China)

机构地区：[1]浙江大学医学院附属第一医院超声医学科,浙江省脉冲电场技术医学转化重点实验室,杭州310006

出　　处：《介入放射学杂志》2022年第5期511-514,共4页Journal of Interventional Radiology

基　　金：国家重大科研仪器研制项目(82027803);国家自然科学基金面上项目(81971623);浙江省自然科学基金重点项目(LZ20H180001)。

摘　　要：不可逆电穿孔(IRE)是一种新型非热能消融方法,该技术利用高压脉冲电场在细胞膜上形成不可逆纳米级微孔,而不损伤周围重要血管或胆管结构,具有并发症少、安全性高和恢复快等优点,在肝癌治疗中展现出广阔的应用前景。本文对IRE技术在肝癌消融治疗中的作用机制、应用优势、有效性、安全性和发展方向作一介绍,以期为该技术的临床应用和推广提供参考。The irreversible electroporation(IRE)is a novel method of non-thermal ablation.IRE generates instantaneous high-voltage pulse electric field to create permanent“nanometer-scale”micropores in the cell membrane,while not damaging the surrounding important blood vessels and bile duct.IRE carries several advantages such as less complications,high safety,quick recovery,etc.,which shows that it has a broad application prospect in treating liver cancers.This article aims to make a comprehensive review about IRE treatment for liver cancer ablation,focusing on its mechanism,application advantages,effectiveness,safety and future development direction so as to provide reference for its clinical application and promotion.

关 键 词：不可逆电穿孔 肝癌 纳米刀 消融 

分 类 号：R735.7[医药卫生—肿瘤]