白花蛇舌草注射液联合经肝动脉化疗栓塞术治疗原发性肝癌患者的效果  

Effects of Hedyotis diffusa injection combined with transarterial chemoembolization in treatment of patients with primary liver cancer

作　　者：杨慧君[1] 井小会[2] YANG Huijun;JING Xiaohui(Pingdingshan People’s Hospital No.1,Department of Medicinal Materials,Pingdingshan 467000 Henan,China;Pingdingshan People’s Hospital No.1,Department of Oncology,Pingdingshan 467000 Henan,China)

机构地区：[1]平顶山市第一人民医院药材科,河南平顶山467000 [2]平顶山市第一人民医院肿瘤科,河南平顶山467000

出　　处：《中国民康医学》2022年第13期107-109,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察白花蛇舌草注射液联合经肝动脉化疗栓塞术治疗原发性肝癌患者的效果。方法:回顾性分析2017年4月至2020年4月该院收治的70例原发性肝癌患者的临床资料,根据治疗方式不同将其分为对照组与观察组各35例。对照组采用经肝动脉化疗栓塞术治疗,观察组在对照组基础上联合白花蛇舌草注射液治疗,比较两组临床疗效、治疗前后T细胞亚群指标(CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))水平,以及不良反应发生率。结果:观察组疾病控制率为88.57%(31/35),高于对照组的68.57%(24/35),差异有统计学意义(P<0.05);治疗后,对照组CD4^(+)、CD4^(+)/CD8^(+)水平均低于治疗前,CD8^(+)水平高于治疗前,观察组CD4^(+)、CD4^(+)/CD8^(+)水平均高于治疗前,CD8^(+)水平低于治疗前,且观察组CD4^(+)、CD4^(+)/CD8^(+)水平高于对照组,CD8^(+)水平低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:白花蛇舌草注射液联合经肝动脉化疗栓塞术治疗原发性肝癌患者可提高疾病控制率,以及改善T细胞亚群指标水平,其效果优于单纯经肝动脉化疗栓塞术治疗。Objective:To observe effects of Hedyotis diffusa injection combined with transarterial chemoembolization in treatment of patients with primary liver cancer.Methods:The clinical data of 70 patients with primary liver cancer admitted to our hospital from April 2017 to April 2020 were retrospectively analyzed.They were divided into control group and observation group according to different treatment methods,35 cases in each.The control group was treated with transarterial chemoembolization,while the observation group was treated with Hedyotis diffusa injection on the basis of that of the control group.The clinical efficacy,the T cell subset index levels(CD4^(+),CD8^(+),CD4^(+)/CD8^(+))and incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The disease control rate of the observation group was 88.57%(31/35),which was higher than the control group of 68.57%(24/35),and the difference was statistically significant(P<0.05).After the treatment,the levels of CD4^(+)and CD4^(+)/CD8^(+)in the control group were lower than those before the treatment,and the level of CD8^(+)was higher than that before the treatment;the levels of CD4^(+)and CD4^(+)/CD8^(+)in the observation group were higher than those before the treatment,and the level of CD8^(+)was lower than before the treatment;the levels of CD4^(+)and CD4^(+)/CD8^(+)in the observation group were higher than those in the control group,and the level of CD8^(+)was lower than that of the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Hedyotis diffusa injection combined with transarterial chemoembolization in the treatment of the patients with primary liver cancer can improve the disease control rate and improve the levels of T cell subsets.Moreover,it is superior to single transarterial chemoembolization.

关 键 词：原发性肝癌 白花蛇舌草注射液 经肝动脉化疗栓塞术 T细胞亚群 不良反应 

分 类 号：R73[医药卫生—肿瘤]