普通感冒与肿瘤发病关系的病例对照研究  

The relationship between common cold and the risk of cancer:A case-control study

作　　者：李芊芊 李凌宇 陈循睿 张文颖[1] 袁海花[1] 张燕捷[1] 姜斌[1] 刘峰[1] LI Qianqian;LI Lingyu;CHEN Xunrui;ZHANG Wenying;YUAN Haihua;ZHANG Yanjie;JIANG Bin;LIU Feng(Department of Oncology,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 201999,China;Shanghai Jiao Tong University School of Medicine,Shanghai 200023,China)

机构地区：[1]上海交通大学医学院附属第九人民医院肿瘤科,上海201999 [2]上海交通大学医学院,上海200023

出　　处：《现代肿瘤医学》2022年第16期2981-2985,共5页Journal of Modern Oncology

基　　金：上海交通大学医学院附属第九人民医院临床研究助推计划(临+项目)(编号:JYLJ202019)。

摘　　要：目的:观察普通感冒对肿瘤发病风险的影响。方法:2021年1月至2021年5月,连续收集综合医院和社区医院就诊的532例肿瘤患者作为病例组,按年龄、性别、长期居住地进行1∶1匹配,收集同期同地点532名未患肿瘤者作为对照组。通过问卷调查、查阅门诊或住院病历的方式获取患者的临床资料。采用条件logistic回归进行单因素和多因素分析感冒对肿瘤发病风险的影响。结果:单因素分析显示,感冒的频率在病例组和对照组中有统计学差异(P<0.05)。多因素分析显示,与每年感冒次数少于1次相比,每年患1次感冒(OR=0.461,95%CI:0.327~0.649),患2次感冒(OR=0.224,95%CI:0.145~0.347),患3次及以上感冒(OR=0.092,95%CI:0.046~0.182)肿瘤的发病风险降低。结论:一定频率的普通感冒可能与肿瘤发病风险降低有关。Objective:To observe the effect of common cold on the risk of cancer.Methods:From January 2021 to May 2021,we identified 532 patients with cancer who visited general hospitals and community hospitals as a case group and 532 participants without cancer matching by age,gender and region of residency as a control group.Clinical data were obtained by questionnaire survey and medical records.Univariate,and multivariate analyses were used for statistical analysis.Results:The results showed that there was significant difference in the frequency of cold between the two groups(P<0.05)in univariate analysis.In multivariate analysis,compared with participants who with less than one time cold per year,one time cold per year(OR=0.461,95%CI:0.327~0.649),two times colds per year(OR=0.224,95%CI:0.145~0.347),and three or more times colds per year(OR=0.092,95%CI:0.046~0.182)associated with decreased risk of cancer.Conclusion:The results suggest that a certain frequency of common cold could be associated with a reduced risk of cancer.

关 键 词：普通感冒 肿瘤发病风险 配对病例对照研究 

分 类 号：R730.231[医药卫生—肿瘤]