生物化学综合性虚拟仿真实验建设与教学探索  

Construction and Teaching Exploration of Synthetic Virtual Simulation Experiment of Biochemistry

作　　者：史影 王伟伟[1] 周耐明 霍颖异[1,2] 应颖慧[1,2] 吴敏 SHI Ying;WANG Weiwei;ZHOU Naiming;HUO Yingyi;YING Yinghui;WU Min(College of Life Sciences,Zhejiang University,Hangzhou 310058,China;National Demonstration Center For Experimental Biology Education,Zhejiang University,Hangzhou 310058,China)

机构地区：[1]浙江大学生命科学学院,杭州310058 [2]浙江大学生物学国家级实验教学示范中心,杭州310058

出　　处：《实验室研究与探索》2022年第4期154-158,共5页Research and Exploration In Laboratory

基　　金：国家自然科学基金面上项目(32070771);浙江省“十三五”高校虚拟仿真实验建设项目(浙教办函[2019]365号)。

摘　　要：G蛋白偶联受体(GPCR)一直是生物学研究热点及新药研发靶标。采用虚拟仿真实验技术,以G蛋白偶联受体FPR1为载体,全线模拟全基因克隆及真核表达,并进行功能研究的整个实验过程。该虚拟仿真实验有助于学生更深入且系统地认识GPCR的结构和功能、信号转导过程及相关研究方法和实验技术,培养综合性研究型实验能力。教学实践表明,虚拟仿真实验和实体实验的有效融合,能促进教学内容和教学效果的提升。综合性虚拟仿真实验在辅助教学及课程衔接中也可发挥其独特作用。G protein coupled receptors have been hotspots of biological research and development targets of new drug.Using virtual simulation technology and G-protein coupled receptor FPR1,the whole experimental procedures of gene cloning,eukaryotic expression and its functional detection are virtualized.The virtual simulation experiment is helpful for students to understand the structure and function of GPCR,signal transduction and related research methods and experimental techniques.The teaching practice suggests that the combination of virtual experiment and physical experiment can promote the improvement of teaching content and teaching effect.The comprehensive virtual simulation experiment can also play a unique role in the auxiliary teaching and curriculum connection.

关 键 词：虚拟仿真实验 G蛋白偶联受体 虚实结合教学 

分 类 号：Q5-33[生物学—生物化学] G642[文化科学—高等教育学]