褪黑素抗衰老机制及其与缺血性卒中的关系  

The Anti-aging Mechanism of Melatonin and Its Relationship with Ischemic Stroke

作　　者：张佳丽 陈楚歆 张心怡 张宁[1,2] 王春雪 ZHANG Jiali;CHEN Chuxin;ZHANG Xinyi;ZHANG Ning;WANG Chunxue(Department of Neuropsychiatry and Clinical Psychology,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China;China National Clinical Research Center for Neurological Diseases,Beijing 100070,China;Beijing Institute of Brain Disorders,Beijing 100070,China)

机构地区：[1]首都医科大学附属北京天坛医院神经精神医学与临床心理科,北京100070 [2]国家神经系统疾病临床医学研究中心 [3]北京脑重大疾病研究院

出　　处：《中国卒中杂志》2022年第7期791-796,共6页Chinese Journal of Stroke

基　　金：国家重点研发计划(2020YFC2005304,2016YFC1307205)。

摘　　要：褪黑素具有显著抗衰老作用,其主要机制包括自由基清除和线粒体保护,褪黑素水平的下降可能是人体衰老的表现。此外,研究证实褪黑素具有降脂、降压和减重作用,可预防和延缓动脉粥样硬化进展,改善脑缺血再灌注损伤,在缺血性卒中领域具有良好的应用前景。本文对褪黑素抗衰老、预防卒中相关危险因素和改善卒中预后等方面的作用机制和应用前景进行总结。Melatonin has significant anti-aging effect,and the main action mechanisms includes free radical scavenging and mitochondrial protection.The decline of melatonin level may be the manifestation of human aging.In addition,it has been confirmed that melatonin has the effect of lipid-lowering,antihypertension and weight-loss,which can prevent and delay the progression of atherosclerosis,and reduce ischemia-reperfusion injury,so melatonin has a good application prospect in the field of ischemic stroke.This article summarized the mechanism and application prospect of melatonin in anti-aging,preventing stroke related risk factors and improving stroke prognosis.

关 键 词：褪黑素 抗衰老 缺血性卒中 

分 类 号：R743.3[医药卫生—神经病学与精神病学]