阿托伐他汀钙治疗老年冠心病的效果及对患者血脂管理的影响研究  

Study on the effect of atorvastatin calcium in the treatment of elderly coronary heart disease and its influence on the management of blood lipids in patients

作　　者：王逵 WANG Kui(Department of Cardiology,First People's Hospital of Liangjiang New District,Chongqing 401211,China)

机构地区：[1]重庆市两江新区第一人民医院心内科,401211

出　　处：《中国实用医药》2022年第15期111-113,共3页China Practical Medicine

摘　　要：目的 探讨阿托伐他汀钙对老年冠心病患者血脂管理效果的影响。方法 76例老年冠心病患者,以随机数字表法分为观察组与对照组,各38例。对照组患者采用常规治疗,观察组在对照组基础上加用阿托伐他汀钙治疗。对比两组治疗前后的血脂管理效果、疗效、不良反应发生率。结果 治疗后,两组的甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平均较治疗前改善,且观察组TG(1.12±0.26)mmol/L、TC(2.53±0.30)mmol/L、LDL-C(1.12±0.16)mmol/L均低于对照组的(2.51±0.35)、(3.95±0.79)、(2.26±0.19)mmol/L,HDL-C(1.85±0.42)mmol/L高于对照组的(1.36±0.35)mmol/L,差异有统计学意义(P<0.05)。观察组治疗总有效率为97.37%,高于对照组的84.21%,差异有统计学意义(P<0.05)。观察组不良反应发生率为5.26%,与对照组的7.89%对比,差异无统计学意义(P>0.05)。结论 对于老年冠心病患者通过给予阿托伐他汀钙治疗可有效提升其血脂管理效果并进一步提升治疗总有效率,且用药安全性良好,该用药方案值得临床推广和应用。Objective To investigate the effect of atorvastatin treatment on blood lipid management in elderly patients with coronary heart disease.Methods A total of 76 elderly patients with coronary heart disease were randomly divided into observation group and control group,with 38 cases in each group.Patients in the control group were treated with conventional treatment,and patients in the observation group were additionally treated with atorvastatin calcium on the basis of the control group.The effect of blood lipid management before and after treatment,clinical efficacy and incidence of adverse reactions were compared between the two groups.Results After treatment,the levels of triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C)and low-density lipoprotein cholesterol(LDL-C)in the two groups were improved compared with those before treatment in this group;the TG(1.12±0.26)mmol/L,TC(2.53±0.30)mmol/L,and LDL-C(1.12±0.16)mmol/L in the observation group were lower than(2.51±0.35),(3.95±0.79),and(2.26±0.19)mmol/L in the control group, and the HDL-C (1.85±0.42) mmol/L was higher than (1.36±0.35) mmol/L in the control group;all the differences were statistically significant (P<0.05). The total effective rate of the observation group was 97.37%, which was higher than 84.21% of the control group, and the difference was statistically significant (P<0.05). The incidence of adverse reactions in the observation group was 5.26%, which was not statistically significant (P>0.05) compared with 7.89% in the control group. Conclusion For elderly patients with coronary heart disease, atorvastatin calcium treatment can effectively improve the effect of blood lipid management and further improve the total effective rate, with high drug safety. This drug regimen is worthy of clinical promotion and application.

关 键 词：冠心病 阿托伐他汀钙 血脂 管理效果 

分 类 号：R541.4[医药卫生—心血管疾病]