抗精神病药物联合帕罗西汀治疗精神分裂症的效果分析  

Effect analysis of antipsychotic drugs combined with paroxetine in the treatment of schizophrenia

作　　者：赵辉 ZHAO Hui(Xinkang Hospital of Daxing District,Beijing 102600,China)

机构地区：[1]北京市大兴区心康医院一科,102600

出　　处：《中国实用医药》2022年第15期157-160,共4页China Practical Medicine

摘　　要：目的 分析抗精神病药物联合帕罗西汀治疗精神分裂症的临床效果。方法 76例精神分裂症患者,采用随机数字表法分为对照组和观察组,各38例。对照组患者应用抗精神病药物进行治疗,观察组患者应用抗精神病药物联合帕罗西汀治疗。对比两组患者治疗前后阳性和阴性症状量表(PANSS)评分及临床疗效、不良反应发生率。结果 治疗前,两组患者阳性症状、阴性症状、精神病理评分及总得分对比,差异无统计学意义(P>0.05);治疗4周,观察组阳性症状、阴性症状、精神病理评分及总得分分别为(12.05±2.06)、(38.01±3.85)、(21.62±4.95)、(75.59±7.39)分,均低于对照组(13.62±2.62)、(41.19±5.18)、(25.39±5.61)、(80.09±8.19)分,差异具有统计学意义(P<0.05);治疗12周,观察组阳性症状、阴性症状评分、精神病理评分及总得分分别为(11.01±2.62)、(34.15±2.09)、(21.06±5.18)、(71.02±8.35)分,均低于对照组的(13.11±3.52)、(40.61±3.79)、(24.53±6.85)、(78.29±9.69)分,差异具有统计学意义(P<0.05)。观察组治疗总有效率94.74%高于对照组的76.32%,差异具有统计学意义(P<0.05)。观察组不良反应发生率7.89%与对照组的10.53%对比,差异无统计学意义(P>0.05)。结论 对精神分裂症患者应用抗精神病药物联合帕罗西汀治疗的效果满意,可有效改善患者的临床症状并显著提升疗效,同时安全性良好。Objective To analyze the clinical effect of antipsychotic drugs combined with paroxetine in the treatment of schizophrenia.Methods A total of 76 patients with schizophrenia were divided into control group and observation group according to random numerical table,with 38 cases in each group.Patients in the control group were treated with antipsychotic drugs,and patients in the observation group were treated with antipsychotic drugs combined with paroxetine.The positive and negative syndrome scale(PANSS)scores before and after treatment,clinical efficacy and incidence of adverse reactions were compared between the two groups.Results Before treatment,there was no statistically significant difference in positive symptoms,negative symptoms,psychopathological scores and total scores between the two groups(P>0.05).After 4 weeks of treatment,the positive symptoms,negative symptoms,psychopathological scores and total scores of the observation group were(12.05±2.06),(38.01±3.85),(21.62±4.95),and(75.59±7.39)points,which were lower than(13.62±2.62),(41.19±5.18),(25.39±5.61),and(80.09±8.19)points of the control group,and the differences were statistically significant(P<0.05).After 12 weeks of treatment,the positive symptoms,negative symptoms,psychopathological scores and total scores of the observation group were(11.01±2.62),(34.15±2.09),(21.06±5.18),and(71.02±8.35)points,which were all lower than(13.11±3.52),(40.61±3.79),(24.53±6.85),and(78.29±9.69)points of the control group,and the differences were statistically significant(P<0.05).The total effective rate 94.74%of the observation group was higher than 76.32%of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 7.89%,which was not statistically significant compared with 10.53%in the control group(P>0.05).Conclusion Antipsychotic drugs combined with paroxetine in patients with schizophrenia is satisfactory and can effectively improve the clinical symptoms and significantl

关 键 词：精神分裂症 抗精神病药 帕罗西汀 阳性和阴性症状量表 

分 类 号：R749.3[医药卫生—神经病学与精神病学]