高压氧联合驱铜疗法治疗脑型肝豆状核变性的临床研究  

Clinical study of hyperbaric oxygen combined with copper flooding in the treatment of hepatolenticular degeneration

作　　者：刁胜朋[1] 杨驱云[1] 黄叶青[1] 刘爱群[1] 洪铭范[1] DIAO Shengpeng;YANG Quyun;HUANG Yeqing;LIU Aiqun;HONG Mingfan(The First Affiliated Hospital of Guangdong Pharmaceutical University,Gu angzhou Guangdong 510080)

机构地区：[1]广东药科大学附属第一医院,广东广州510080

出　　处：《当代医药论丛》2022年第15期70-73,共4页

基　　金：广东省医学科学技术研究基金项目,B2020126。

摘　　要：目的:研究用高压氧联合驱铜疗法治疗脑型肝豆状核变性(WD)的临床疗效。方法:选择2019年1月至2021年12月在广东药科大学附属第一医院接受诊治的脑型WD病例40例〔平均年龄(27.05±6.79)岁〕,将其随机分为观察组和对照组(20例/组)。为观察组患者采用二巯基丙磺钠驱铜联合高压氧疗法进行治疗(二巯基丙磺钠驱铜治疗以8d为1个疗程,共治疗2个疗程;高压氧治疗以6 d为1个疗程,共治疗2个疗程),为对照组患者单用二巯基丙磺钠驱铜疗法进行治疗(方法同上)。然后比较两组患者的治疗效果。结果:1)治疗前,两组患者血清SOD、MDA的水平相比,差异无统计学意义(P>0.05)。治疗后,观察组患者血清SOD的水平较治疗前显著升高,且高于对照组患者治疗后血清SOD的水平,差异有统计学意义(P<0.05)。治疗后,两组患者血清MDA的水平与治疗前相比,差异无统计学意义(P>0.05);两组患者血清MDA的水平相比,差异无统计学意义(P>0.05)。2)治疗前,两组患者的BFM-M评分相比,差异无统计学意义(P>0.05)。治疗后,观察组患者的BFM-M评分较治疗前显著降低,且低于对照组患者治疗后的BFM-M评分,差异有统计学意义(P<0.05)。结论:对脑型WD患者进行高压氧联合驱铜治疗可显著改善其神经症状,保护其神经功能。Objective:To study the clinical efficacy of hyperbaric oxygen combined with copper flooding in the treatment of cerebral Wilson’s disease(WD).Methods:A total of 40 cerebral WD patients(me an age(27.05±6.79)years old)admitted to the First Affiliated Hospital of Guangdong Pharmaceutical University from January 2019 to December 2021 were randomly divided into observation group and control group(20 cases/group).For the observation group,patients were treated with dimercaptopropyl sodium copper displace combined with hyperbaric oxygen therapy(dimercaptopropyl sodium copper displace for 8 days as a course,a total of 2 courses of treatment;Hyperbaric oxygen therapy was performed for 6 days as a course of treatment,with a total of 2 courses of treatment),and patients in the control group were treated with dimercaptopropyl sodium copper displacement therapy alone(the method was the same as above).Then the treatment effects of the two groups were compared.Results:1)Before treatment,there was no significant difference in the levels of SOD and MDA in serum between 2 groups(P>0.05).After treatment,the serum SOD level in observation group was significantly higher than that in control group,and the difference was statistically significant(P<0.05).After treatment,there was no significant difference in serum MDA level between 2 groups compared with before treatment(P>0.05).There was no significant difference in serum MDA level between 2 groups(P>0.05).2)Before treatment,there was no significant difference in BFM-M score between 2 groups(P>0.05).After treatment,the BFM-M score of the observation group was significantly lower th an that before treatment,and lower than that of the control gr oup,with statistical significance(P<0.05).Conclusion:Hyperbaric oxygen combined with copper flooding can significantly improve the neurological symptoms and protect the neurological function of WD patients with brain type.

关 键 词：肝豆状核变性 神经症状 脑型 高压氧 驱铜 

分 类 号：R742[医药卫生—神经病学与精神病学]