不同程度老年阿尔茨海默病患者血清S100β、ABAb、脂联素水平检测及其与认知功能的相关性  

The detection of levels of serum S100β,ABAb and adiponectin in elderly patients with different degrees of Alzheimer’s disease and their correlation with cognitive function

作　　者：郑春妹 周经霞[2] 郑春娇 陈元椿[1] 吴惠[1] Zheng Chun-mei;Zhou Jing-xia;Zheng Chun-jiao;Chen Yuan-chun;Wu Hui(Hainan Cadre Sanatorium/Hainan Geriatric Hospital,Hainan 571100,China;The Second Affiliated Hospital of Hainan Medical Univer-sity,Haikou 570311,China)

机构地区：[1]海南省干部疗养院/海南省老年病医院,海口571100 [2]海南医学院第二附属医院,海口570311

出　　处：《湖南师范大学学报（医学版）》2022年第3期159-162,共4页Journal of Hunan Normal University(Medical Sciences)

摘　　要：目的:探究不同程度老年阿尔茨海默病患者血清S100β、ABAb、脂联素水平及其与认知功能的相关性.方法:选择2016年3月~2019年5月在我院确诊的115例阿尔茨海默病(AD)患者作为AD组,采用临床痴呆评定量表(CDR)将AD组分为轻度组32例,中度组39例,重度组44例.另选择同期在我院进行健康体检的50例非AD体检人群作为对照组.采用酶联免疫吸附法(ELISA)检测两组受检者的血清S100β蛋白、抗脑抗体(ABAb)、脂联素(APN)水平,另采用简易精神状态量表(MMSE)对其认知功能进行评价.对比两组受检者以及不同程度AD患者的血清S100β、ABAb、APN水平及MMSE评分.采用Pearson相关分析法对AD患者S100β、ABAb、APN与认知功能的相关性进行分析.结果:AD组患者的S100β、ABAb水平明显高于对照组,APN和MMSE评分明显低于对照组,差异比较有统计学意义.重度组的S100β、ABAb水平明显高于中度组和轻度组,APN和MMSE评分均明显低于中度组和轻度组,中度组的S100β、ABAb水平明显高于轻度组,APN和MMSE评分均明显低于轻度组,三组患者的S100β、ABAb、APN及MMSE评分比较差异有统计学意义.相关性分析显示,AD患者的S100β、ABAb与MMSE评分呈负相关,AD患者的APN水平与MMSE评分呈正相关.AD患者的S100β与ABAb呈正相关,S100β与APN呈负相关,AD患者的ABAb与APN呈负相关.结论:老年阿尔茨海默病患者发病时,其血清S100β、ABAb水平明显升高,APN水平明显下降,血清S100β、ABAb和APN水平与其认知功能减退存在一定相关性,观察其变化能够在一定程度上体现其认知功能损害程度.Objective To research the levels of serum S100β,ABAb and adiponectin in elderly patients with different de-grees of Alzheimer’s disease and their correlation with cognitive function.Methods From March 2016 to May 2019,115 pa-tients with Alzheimer’s disease(AD)who diagnosed in our hospital were selected as the AD group.The AD group was divided into mild group(32 cases),moderate group(39 cases)and severe group(44 cases)by clinical dementia rating scale(CDR).In addition,50 non-AD people who underwent health examination in our hospital during the same period were selected as the con-trol group.The levels of serum S100βprotein,anti-brain antibody(ABAb)and adiponectin(APN)were detected by enzyme-linked immunosorbent assay(ELISA),and cognitive function was evaluated by Mini-Mental State Scale(MMSE).The levels of serum S100β,ABAb,APN and MMSE scores were compared between the two groups and the AD patients of different degrees.Pearson correlation analysis was used to analyze the correlation between S100β,ABAb,APN and cognitive function in AD pa-tients.Results The levels of S100βand ABAb in AD group were significantly higher than those in control group,and the scores of APN and MMSE in AD group were significantly lower than those in control group.The levels of S100βand ABAb in severe group were significantly higher than those in moderate group and mild group.The scores of APN and MMSE were significantly lower than those in moderate group and mild group.The levels of S100βand ABAb in moderate group were significantly higher than those in mild group.The scores of APN and MMSE were significantly lower than those in mild group.There were significant differences in the scores of S100β,ABAb,APN and MMSE among the three groups.The correlation analysis showed that S100βand ABAb were negatively correlated with MMSE score in AD patients,and APN level was positively correlated with MMSE score in AD patients.There was a positive correlation between S100βand ABAb in AD patients,a negative correlation between S100βand APN

关 键 词：阿尔茨海默病 血清S100Β蛋白 抗脑抗体 脂联素 认知功能 

分 类 号：R749.16[医药卫生—神经病学与精神病学]