体质指数和绝经后乳腺癌患者临床病理因素的关系  

Relationship between body mass index and clinicopathological factors of postmenopausal breast cancer

作　　者：王昭君 马海广 胡晓清 陈美华 WANG Zhao-Jun;MA Hai-Guang;HU Xiao-Qing(Department of Oncology,Wenzhou Central Hospital,Wenzhou,Zhejiang 325000,China)

机构地区：[1]温州市中心医院肿瘤外科,浙江温州325000

出　　处：《中国妇幼保健》2022年第12期2144-2147,共4页Maternal and Child Health Care of China

基　　金：浙江省医药卫生科技计划面上项目(2019KY657);浙江省温州市科技局科技计划项目(Y20190754)。

摘　　要：目的探讨肥胖与绝经后乳腺癌临床病理因素之间的关系。方法选取2014年10月—2016年3月温州市中心医院收治的120例绝经后乳腺癌患者为研究对象,测量身高、体质量并计算体质指数(BMI),分析BMI与临床病理特征的相关性。结果非超重肥胖组(BMI<24 kg/m^(2))年龄>60岁者44例(27.4%),肿块直径≥2 cm者27例(43.5%);超重肥胖组(BMI≥24 kg/m^(2))年龄>60岁者27例(44.6%),肿块直径≥2 cm者37例(63.8%);两组患者年龄、肿瘤直径比较,差异均有统计学意义(χ^(2)=4.724、4.935,均P<0.05)。非超重肥胖组和超重肥胖组患者其他临床病理特征比较,差异均无统计学意义(均P>0.05)。多元线性回归分析结果显示,BMI值和家族史是影响肿瘤大小的独立危险因素(均P<0.05)。Kaplan-Meier生存分析显示,BMI对绝经后乳腺癌患者OS的影响差异无统计学意义(P>0.05)。结论绝经后乳腺癌患者的BMI水平与年龄、肿瘤大小密切相关,应重视控制体质量、规范检查以利于早期发现肿瘤,及时治疗。Objective To investigate the relationship between obesity and clinicopathological factors of postmenopausal breast cancer.Methods 120 postmenopausal breast cancer patients admitted to Wenzhou Central Hospital were selectedfor the study from October 2014 to March 2016.The correlation between BMI and clinicopathological characteristics was analyzed by measuring height and body mass and calculating body mass index(BMI).Results In the non-overweight obese group(BMI<24 kg/m^(2)),44 cases(27.4%)were aged>60 years,and 27 patients(43.5%)with mass≥2 cm;in the overweight obese group(BMI≥24 kg/m^(2)),27 cases(44.6%)were aged>60 years,and 37 cases(63.8%)with mass≥2 cm.Research showed close correlation in age and tumor sizebetween the two groups(χ^(2)=4.724,4.935,P<0.05),whilenocorrelationinother clinicopathological features(P>0.05).Multiple linear regression analysis showed that BMI and family history were independent risk factors for tumor size(P<0.05).Kaplan-Meier survival analysisshowed that BMI had no significant effect on OS in postmenopausal patients(P>0.05).Conclusion The BMI level of postmenopausal breast cancer patients is closely related to their age and tumor size,so we should pay attention to the control of body mass and standardized examination to facilitate early detection of tumor and timely treatment.

关 键 词：绝经后 乳腺癌 体指指数 肥胖 

分 类 号：R737.9[医药卫生—肿瘤]