北京地区人群发生胆囊结石的影响因素分析  

Analysis of influencing factors for the development of gallstone in population of Beijing

作　　者：王智弘 李佳颐 花苏榕[1] 汤博 洪涛[1] 刘卫[1] 何小东[1] Wang Zhihong;Li Jiayi;Hua Surong;Tang Bo;Hong Tao;Liu Wei;He Xiaodong(Department of General Surgery,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing 100730,China;Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;Department of Anesthesiology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医院基本外科,北京100730 [2]中国医学科学院北京协和医学院,北京100730 [3]中国医学科学院北京协和医院麻醉科,北京100730

出　　处：《中华消化外科杂志》2022年第7期910-916,共7页Chinese Journal of Digestive Surgery

摘　　要：目的探讨北京地区人群发生胆囊结石的影响因素。方法采用回顾性横断面调查研究方法。2016年11月至2020年9月,以中国医学科学院北京协和医院基本外科胆道门诊初次就诊北京本地患者(户籍在北京时间≥12个月)为调查对象,设计《饮食习惯与胆囊结石发病率的相关性调查》问卷进行调查研究。问卷内容包括:性别,年龄,体质量指数(BMI),胆囊结石情况,代谢指标(高胆固醇血症、糖尿病史、女性生育次数、女性绝经情况、女性绝经者绝经时长、体质量下降史),饮食指标(饮食荤素搭配情况、每月摄取咖啡次数、每月饮酒次数、每月摄取油腻饮食次数、每周不吃早餐次数、不吃早餐的平均隔夜禁食时间、每周不吃晚餐次数、不吃晚餐的平均隔夜禁食时间),胆囊结石家族史,生活习惯(每月熬夜次数、熬夜时的平均隔夜禁食时间、每天久坐时间、每周体育锻炼评分)。观察指标:(1)问卷调查结果。(2)影响胆囊结石发生因素。正态分布的计量资料以x±s表示,偏态分布的计量资料以M(Q 1,Q 3)表示。计数资料以绝对数表示。单因素及多因素分析采用Logistic回归模型。结果(1)问卷调查结果。共发放问卷1036份,收回完整问卷1004份。1004例完成问卷调查的患者中,男329例、女675例;年龄为(44±12)岁;BMI为(24±3)kg/m^(2)。1004例患者中,有胆囊结石史659例,无胆囊结石史345例。(2)影响胆囊结石发生因素分析。单因素分析结果显示:年龄、糖尿病史、体质量下降史、每月摄取咖啡次数、每月摄取油腻饮食次数、胆囊结石家族史、每天久坐时间是影响1004例问卷调查患者发生胆囊结石的相关因素(比值比=1.03,2.26,1.74,1.01,1.01,2.22,1.06,95%可信区间为1.02~1.05,1.09~5.18,1.22~2.53,1.00~1.03,1.00~1.01,1.60~3.11,1.01~1.11,P<0.05)。多因素分析结果显示:年龄、糖尿病史、体质量下降史、每月摄取油腻饮食次数、胆囊�Objective To investigate the influencing factors for the development of gall-stone in population of Beijing.Methods The retrospective cross-sectional survey was conducted.From November 2016 to September 2020,patients living in Beijing(registered residence in Beijing≥12 months)who visited the biliary outpatient of Department of General Surgery of Peking Union Medical College Hospital,Chinese Academy of Medical Sciences for the first time were recruited to participate as respondents.The survey was conducted by the questionnaire survey on correlation between dietary habits and incidence of gallstones,in which the information of gender,age,body mass index(BMI),gallstone status,metabolic indicators(hypercholesterolemia,history of diabetes mellitus,reproductive times for female,menopause status of female,duration of menopause for female,history of weight loss),dietary indicators(dietary mix of meat and vegetable dishes,times of coffee intake per month,times of alcohol consumption per month,times of greasy diet intake per month,times of breakfast skipping per week,average overnight fasting time of breakfast skipping,times supper skipping per week,average overnight fasting time of supper skipping),family history of gallstones,lifestyle indicators(times of staying up late per month,average overnight fasting time when staying up late,daily sedentary time,weekly physical activity score).Observation indicators:(1)results of questionnaire survey;(2)analysis of influencing factors for the occurrence of gallstone.Measurement data with normal distribution were represen-ted as Mean±SD,and measurement data with skewed distribution were represented as M(Q 1,Q 3).Count data were expressed as absolute numbers or percentages.Univariate and multivariate analyses were performed using the Logistic regression model.Results(1)Results of questionnaire survey.A total of 1036 questionnaires were distributed,and 1004 complete questionnaires were recovered.Of the 1004 patients who completed the questionnaire survey,there were 329 males and 6

关 键 词：胆道疾病 结石 影响因素 饮食习惯 生活习惯 

分 类 号：R575.62[医药卫生—消化系统]