Short and long term corneal biomechanical analysis after overnight orthokeratology  

作　　者：Amelia Nieto-Bona Paloma Porras-Ángel Adela Elena Ayllón-Gordillo Gonzalo Carracedo David P Piñero 

机构地区：[1]Department of Optometry&Vision,Optics and Optometry Faculty,Complutense University of Madrid,Madrid 28037,Spain [2]Department of Optics,Pharmacology and Anatomy,University of Alicante,Alicante 03690,Spain

出　　处：《International Journal of Ophthalmology(English edition)》2022年第7期1128-1134,共7页国际眼科杂志（英文版）

基　　金：Supported by the Ministry of Economy;Industry and Competitiveness of Spain within the program Ramón y Cajal,RYC-2016-20471。

摘　　要：AIM: To investigate the short and long term corneal biomechanical changes after overnight orthokeratology(OK) and compare them with those occurring in subjects not wearing contact lenses.METHODS: Retrospective case control study enrolling 54 subjects that were divided into three groups 18 subjects each: control group(CG), short term(15 nights) OK(STOK) group, and long term(more than 1 y of OK wear) OK(LTOK) group. Corneal biomechanics were characterized using the Cor Vis? ST system(Oculus), recording parameters such as time [first/second applanation time(AT1, AT2)], speed [velocity of corneal apex at the first/second applanation time(AV1, AV2)], and amplitude of deformation(AD1, AD2) in the first and second corneal flattening, corneal stiffness(SPA1), biomechanically corrected intraocular pressure(b IOP) and corneal(CBI) and tomographic biomechanical indices(TBI).RESULTS: Significantly lower AD1 and standard deviate on of Ambrosio’s relational average thickness related to the horizontal profile(ARTh) values were found in the OK groups compared to CG(P<0.05). Likewise, significantly higher values of CBI were found in STOK and LTOK groups compared to CG(P<0.01). No significant differences between groups were found in integrated radius index(P=0.24), strain stress index(P=0.22), tomographic biomechanical index(P=0.91) and corneal stif fness parameter(SPA1, P=0.97). Significant inverse correlations were found between corneal thickness and CBI in STOK(r=-0.90, P<0.01) and LTOK groups(r=-0.71, P<0.01).CONCLUSION: OK does not seem to alter significantly the corneal biomechanical properties, but special care should be taken when analyzing biomechanical parameters influenced by corneal thickness such as amplitude of deformation, ARTh or CBI, because they change significantly after treatment but mainly due to the reduction and pachymetric progression induced by the corneal molding secondary to OK treatment.

关 键 词：overnight orthokeratology corneal biomechanics PACHYMETRY corneal biomechanical index CorVis?ST tomographic biomechanical index 

分 类 号：R779.6[医药卫生—眼科]