肌动蛋白及其结合蛋白在病毒感染复制中作用的研究进展  

Research Progress of the Role of Actin and Actin⁃binding Proteins in Viral Infection and Replication

作　　者：刘红云 刘思华 王涛 王志云 LIU Hongyun;LIU Sihua;WANG Tao;WANG Zhiyun(School of Life Science,Tianjin University,Tianjin 300000,China;School of Environmental Science and Engineering,Tianjin University,Tianjin 300000,China)

机构地区：[1]天津大学生命科学学院,天津300000 [2]天津大学环境科学与工程学院,天津300000

出　　处：《病毒学报》2022年第4期982-990,共9页Chinese Journal of Virology

基　　金：国家重点研发计划(项目号:2017YFA0205102);题目:病毒特异性分子靶标的筛选与纳米标记。

摘　　要：肌动蛋白是真核细胞中最丰富的细胞骨架蛋白,广泛参与细胞运动、维持细胞形态等生物学过程。研究表明肌动蛋白及其结合蛋白在病毒吸附、进入、组装、释放中发挥重要作用,尽管具体的分子机制还不清楚,但致力于探究肌动蛋白及其结合蛋白在病毒感染中的关键调节作用,可为病毒致病机理的研究,潜在抗病毒靶点的挖掘提供理论与实践基础。本文重点介绍肌动蛋白及其结合蛋白在病毒感染各环节中的关键作用。Actin is the most abundant cytoskeleton protein in eukaryotic cells,which participates in fundamental cellular events such as cell movement,morphology maintenance and so on.Studies have shown that actin and its binding proteins are potential involved in the entry,assembly and release of viruses.The study of its key regulatory role in viral infections could provide a theoretical and practical basis for the exploration of pathogenic mechanisms and mining potential antiviral targets,although the specific molecular mechanism is still unclear.This review focuses on summarizing the roles of actin and actin⁃binding proteins in various stages of viral infection.

关 键 词：病毒 肌动蛋白 肌动蛋白结合蛋白 

分 类 号：R-1[医药卫生] R373.9