残余胆固醇与缺血性卒中  

Remnant cholesterol and ischemic stroke

作　　者：赵鑫 蒋欣[2] 崔佩[1,3] 吕佩源 董艳红[2] Zhao Xin;Jiang Xin;Cui Pei;Lyu Peiyuan;Dong Yanhong(Graduate School of North China University of Science and Technology,Tangshan 063000,China;Department of Neurology,Hebei General Hospital,Shijiazhuang 050051,China;Graduate School of Hebei North University,Zhangjiakou 075000,China)

机构地区：[1]华北理工大学研究生院,唐山063000 [2]河北省人民医院神经内科,石家庄050051 [3]河北北方学院研究生院,张家口075000

出　　处：《国际脑血管病杂志》2022年第4期280-284,共5页International Journal of Cerebrovascular Diseases

基　　金：河北省自然科学基金(H2020307042)。

摘　　要：动脉粥样硬化(atherosclerosis,AS)是缺血性卒中发病的病理学基础之一,低密度脂蛋白胆固醇水平升高引起的AS是主要致病因素。然而,最近研究发现传统血脂指标并不能完全反映卒中高危人群的发病风险。非传统血脂参数是在传统血脂参数基础上发展而来,包括残余胆固醇(remnant cholesterol,RC)、非高密度脂蛋白胆固醇和多种血脂比值,可能在脑血管病防治中具有一定作用。其中,RC作为一种驱动AS残余风险的生物学标志物日益得到认可,在卒中一级和二级预防研究中均已证实RC与脑血管病风险密切相关。Atherosclerosis(AS)is one of the pathological bases of ischemic stroke.AS caused by elevated low-density lipoprotein cholesterol levels is the main causative factor.However,recent studies have found that the traditional blood lipid indicators can not fully reflect the risk of stroke in high-risk populations.Non-traditional blood lipid parameters are developed from traditional blood lipid parameters,including remnant cholesterol(RC),non-high density lipoprotein cholesterol and a variety of blood lipid ratios,which may play a role in the prevention and treatment of cerebrovascular diseases.Among them,RC is increasingly recognized as a biomarker driving the residual risk of AS.It has been confirmed that RC is closely associated with the risk of cerebrovascular disease in the primary and secondary prevention studies of stroke.

关 键 词：卒中 脑缺血 胆固醇 脂蛋白类 甘油三酯类 动脉粥样硬化 危险因素 

分 类 号：R743.3[医药卫生—神经病学与精神病学]