经颅多普勒超声评估急性缺血性卒中患者的动态脑血流自动调节  

Transcranial Doppler ultrasound for assessment of dynamic cerebral autoregulation in patients with acute ischemic stroke

作　　者：刘嘉欣 蔺慕会[2] 郭蓉[2] 徐佳亮[2] 张思艺[2] Liu Jiaxin;Lin Muhui;Guo Rong;Xu Jialiang;Zhang Siyi(Dalian Medical University,Dalian 116004,China;Department of Neurology,Liaoning Provincial People’s Hospital,Shenyang 110016,China)

机构地区：[1]大连医科大学,大连116004 [2]辽宁省人民医院神经内科,沈阳110016

出　　处：《国际脑血管病杂志》2022年第4期297-302,共6页International Journal of Cerebrovascular Diseases

基　　金：神经内科临床医学研究中心(201728)。

摘　　要：经颅多普勒(transcranial Doppler,TCD)是一种具有低成本、非侵入性、高时间分辨率等优点的脑动脉血流速度测量方法。动态脑血流自动调节(dynamic cerebral autoregulation,dCA)是研究动脉血压或颅内压变化瞬间的脑血流量(cerebral blood flow,CBF)瞬时变化,即在面对灌注压突然变化时恢复CBF的能力。急性缺血性卒中(acute ischemic stroke,AIS)发病后,有效的dCA可维持脑组织血流动力学稳定,避免损伤部位出现过高或过低灌注。因此,在AIS患者中评估dCA具有重要意义。不过,目前对于dCA尚无公认的最优评估方法。文章主要就TCD对比其他方法评估dCA的优越性以及TCD结合传递函数分析(transfer function analysis,TFA)方法评估dCA在AIS中的应用进行综述。Transcranial Doppler(TCD)is a method for measuring cerebral artery blood flow velocity,which has the advantages of low cost,non-invasive,high temporal resolution.Dynamic cerebral autoregulation(dCA)is to study the instantaneous change of cerebral blood flow(CBF)at the moment of arterial blood pressure or intracranial pressure change,that is,the ability to recover CBF in the face of sudden change of perfusion pressure.After the onset of acute ischemic stroke(AIS),effective dCA can maintain the stability of cerebral hemodynamics and avoid excessive or insufficient perfusion at the injured site.Therefore,it is of great significance to evaluate dCA in patients with AIS.However,at present,there is no recognized optimal evaluation method for dCA.This article mainly summarizes the advantages of TCD in evaluating dCA compared with other methods and the application of TCD combined with transfer function analysis(TFA)in evaluating dCA in AIS.

关 键 词：卒中 脑缺血 脑血管循环 内环境稳定 超声检查 多普勒 经颅 

分 类 号：R743.3[医药卫生—神经病学与精神病学]