射频热凝术联合注射阿霉素治疗三叉神经下颌支痛的临床研究  

Radiofrequency thermocoagulation combined with doxorubicin injection for treatment of trigeminal neuralgia mandibular branch

作　　者：张玲阁 李洁 李继宏 汤宏超 刘玉学[3] Zhang Lingge;Li Jie;Li Jihong;Tang Hongchao;Liu Yuxue(Dept.of Oral and Maxillofacial Surgery,Zhengzhou Stomatologic Hospital,Zhengzhou 450000,China;Dept.of Orthodontics,Zhengzhou Stomatologic Hospital,Zhengzhou 450000,China;Dept.of Oral and Maxillofacial Surgery,Anyang Sixth People’s Hospital,Anyang 455000,China)

机构地区：[1]郑州市口腔医院口腔颌面外科,郑州450000 [2]郑州市口腔医院正畸科,郑州450000 [3]安阳市第六人民医院颌面外科,安阳455000

出　　处：《华西口腔医学杂志》2022年第4期446-450,共5页West China Journal of Stomatology

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ2019-1151)。

摘　　要：目的评价3D打印模板引导射频热凝术联合注射阿霉素治疗三叉神经下颌支痛的临床应用价值。方法将2019年1月—2020年9月在郑州市口腔医院接受射频热凝治疗的50例原发性三叉神经下颌支痛患者随机分为2组,以3D打印模板引导射频热凝术联合注射阿霉素为研究组(n=25),以3D打印模板单纯辅助射频热凝术为对照组(n=25),对比分析2组患者术前,术后即刻及术后1、3、6、12个月时的疼痛情况,即视觉模拟评分(VAS)。采用Brisman三叉神经疼痛疗效评定标准对术后各随访时间段的治疗效果进行评估,并记录术后并发症的情况。结果2组患者术后即刻VAS及术后1、3、6、12个月时的VAS与术前比较均明显下降,差异均有统计学意义(P<0.05);根据Brisman三叉神经痛疗效评定标准,2组患者在术后1和3个月时的有效性差异无统计学意义(P>0.05);术后6和12个月时,研究组的有效性高于对照组,差异均有统计学意义(P<0.05)。研究组患者在随访期间无复发病例,对照组患者在术后3个月时复发1例,术后6个月时复发2例,术后12个月时复发4例;2组患者均未出现明显并发症。结论3D打印模板引导射频热凝术联合注射阿霉素治疗三叉神经下颌支痛,可增强治疗的远期疗效,降低复发率,值得临床推广应用。Objective This study aimed to evaluate the clinical application value of 3D printed template-guided radiofrequency thermocoagulation combined with doxorubicin injection for the treatment of trigeminal neuralgia mandibular branch.Methods A total of 50 patients with primary trigeminal neuralgia mandibular branch in the hospital from January 2019 to September 2020 were randomly divided into two groups:3D printed template-guided radiofrequency thermocoagulation combined with doxorubicin injection was used as the research group(n=25),and 3D printed template guided radiofrequency thermocoagulation was used as the control group(n=25).Comparative analysis of visual analogue score(VAS)was conducted before and immediately after surgery and at 1,3,6,and 12 months after surgery.The Brisman efficacy evaluation criteria for trigeminal neuralgia was used to evaluate the therapeutic effect of each postoperative follow-up period,and postoperative complications were observed.Results The VAS immediately;after surgery and at 1,3,6,and 12 months after surgery in the two groups was significantly lower than that before surgery,with statistical significance(P<0.05).According to Brisman efficacy evaluation criteria for trigeminal neuralgia,no significant difference was found in the efficacy between the two groups at 1 and 3 months after surgery(P>0.05).At 6and 12 months postoperatively,the effectiveness of the research group was higher than that of the control group,and the differences were statistically significant(P<0.05).In the research group,no recurrence occurred during the follow-up period,whereas in the control group,one,two,and four recurrences occurred 3,6,and 12 months after surgery,respectively.No obvious complications were found in both groups.Conclusion 3D printed template-guided radiofrequency thermocoagulation combined with doxorubicin injection for the treatment of trigeminal neuralgia mandibular branch could enhance the long-term curative effect and reduce the recurrence rate,thus worthy of clinical promotion and applica

关 键 词：3D打印模板 射频热凝术 阿霉素 三叉神经痛 下颌支 

分 类 号：R782[医药卫生—口腔医学]