遵义市核苷类似物干预下慢性乙型病毒性肝炎患者乙型肝炎病毒多聚酶区基因突变检测分析  

Detection and Analysis of HBV Polymerase Region Gene Mutations in Patients with Chronic Hepatitis B Under the Intervention of Nucleoside Analogues in Zunyi City

作　　者：杨开余[1] Yang Kai-yu(Guizhou Aerospace Hospital,Zunyi 563000,Guizhou Province,China)

机构地区：[1]贵州航天医院,贵州遵义563000

出　　处：《中国社区医师》2022年第20期93-95,共3页Chinese Community Doctors

基　　金：遵义地区慢性乙肝患者病毒基因型分布及核苷(酸)类似物干预下基因耐药位点研究(编号:2018118号)。

摘　　要：目的:探讨遵义地区慢性乙型病毒性肝炎患者在核苷类似物治疗干预过程中乙型肝炎病毒(HBV)多聚酶区(P)基因的突变类型及发生率。方法:选取2018年12月-2019年12月在贵州航天医院就诊的102例慢性乙型病毒性肝炎患者为研究对象,分析患者在核苷类似物治疗干预后HBV多聚酶区基因的突变类型、突变位点等情况。结果:102例慢性乙型病毒性肝炎患者HBV多聚酶区基因突变类型共19种,其中以单纯rtM204I突变最多(38.24%);核苷类似物耐药率以拉米夫定最高(59.80%)。结论:慢性乙型病毒性肝炎患者HBV多聚酶区基因突变种类较多,且核苷类似物耐药率较高,检测患者HBV多聚酶区基因突变情况有助于指导临床治疗。Objective:To investigate the mutation type and incidence of hepatitis B virus(HBV)polymerase region(P)gene in patients with chronic hepatitis B in Zunyi area during the intervention of nucleoside analogue therapy.Methods:A total of 102patients with chronic hepatitis B who were treated in Guizhou Aerospace Hospital from December 2018 to December 2019 were selected as the study subjects.The mutation types and mutation sites of the HBV polymerase region gene in the patients after the intervention of nucleoside analogue therapy were analyzed.Results:There were 19 types of HBV polymerase region gene mutations in 102 patients with chronic hepatitis B,among which pure rtM204I mutations were dominant(38.24%);the resistance rate of nucleoside analogues was the highest for Lamivudine(59.80%).Conclusion:There are many types of HBV polymerase gene mutations in patients with chronic hepatitis B,and the resistance rate of nucleoside analogues is high.The detection of HBV polymerase gene mutations in patients can help guide clinical treatment.

关 键 词：核苷类似物 慢性乙型病毒性肝炎 HBV多聚酶区 基因突变 

分 类 号：R512.62[医药卫生—内科学]