骨质疏松对中老年重度慢性牙周炎治疗效果的影响  

Effect of osteoporosis on the treatment effect of middle-aged and elderly patients with severe chronic periodontitis

作　　者：陈畅行 刘洪 张利平 邱利华 CHEN Changxing;LIU Hong;ZHANG Liping;QIU Lihua(Department of Periodontology,Nanjing Stomatological Hospital,Medical School of Nanjing University,Jiangsu Province,Nanjing210008,China;School of Medical Technology,Jiangsu Medical Cavational College,Jiangsu Province,Yancheng224005,China;Department of Expert Consultation,Yancheng Stomatological Hospital,Jiangsu Province,Yancheng224000,China;Department of Periodontology,Yancheng Stomatological Hospital,Jiangsu Province,Yancheng224000,China)

机构地区：[1]南京大学医学院附属口腔医院牙周病科,江苏南京210008 [2]江苏医药职业学院医学技术学院,江苏盐城224005 [3]江苏省盐城市口腔医院专家门诊,江苏盐城224000 [4]江苏省盐城市口腔医院牙周病科,江苏盐城224000

出　　处：《中国医药导报》2022年第21期5-8,共4页China Medical Herald

基　　金：国家自然科学基金青年科学基金项目(81800973);江苏省盐城市医学科技发展计划项目(YK2016049)。

摘　　要：目的探讨骨质疏松对中老年重度慢性牙周炎治疗效果的影响。方法将2017年1月至2020年12月在江苏省盐城市口腔医院牙周病科就诊的48例中老年重度慢性牙周炎患者按是否患有骨质疏松症分成观察组与对照组,每组24例。比较两组牙周临床指标[菌斑指数(PLI)、龈沟出血指数(SBI)、牙周袋深度(PD)],炎症因子指标[白细胞介素-1β(IL-1β)、IL-6、肿瘤坏死因子α(TNF-α)]及影像学指标。结果治疗后,两组PLI、SBI、PD低于治疗前,差异有统计学意义(P<0.05)。治疗后,两组牙周临床指标比较,差异无统计学意义(P>0.05)。治疗后,两组各炎症因子水平低于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。结论骨质疏松影响中老年重度慢性牙周炎基础治疗后炎症因子水平和牙槽骨修复再生效果。Objective To investigate the effect of osteoporosis on the treatment effect of middle-aged and elderly patients with severe chronic periodontitis.Methods Forty-eight middle-aged and elderly patients with severe chronic periodontitis who were treated in the Department of Periodontology,Yancheng Stomatological Hospital of Jiangsu Province from January 2017 to December 2020 were selected.According to whether they had osteoporosis or not,they were divided into observation group and control group,with 24 cases in each group.The periodontal clinical indicators(plaque index[PLI],sulcus bleeding index[SBI],periodontal pocket depth[PD]),inflammatory factor indicators(interleukin-1β[IL-1β],IL-6,tumor necrosis factorα[TNF-α]),and imaging indicators.Results After treatment,the PLI,SBI,and PD of the two groups were lower than those before treatment,and the differences were statistically significant(P<0.05).After treatment,there was no significant difference in periodontal clinical indicators between the two groups(P>0.05).After treatment,the levels of inflammatory factors in the two groups were lower than those before treatment,while those of the observation group were higher than those of the control group,and the differences were statistically significant(P<0.05).Conclusion Osteoporosis affects the inflammatory factor levels and the effect of alveolar bone repair and regeneration after basic treatment for middle-aged and elderly patients with severe chronic periodontitis.

关 键 词：骨质疏松 重度慢性牙周炎 炎症因子 牙槽骨修复再生 

分 类 号：R781.4[医药卫生—口腔医学]