脂质因子在非酒精性脂肪肝病中作用机制研究进展  

Research progress of adipokines in nonalcoholic fatty liver disease

作　　者：石项天 徐亚楠 王猛[1] 乔桐杉[1] 乔山[1] 王满仓[1] 欧阳晓晖[2] 苏秀兰[2] SHI Xiangtian;XU Yanan;WANG Meng;QIAO Tongshan;QIAO Shan;WANG Mancang;OUYANG Xiaohui;SU Xiulan(Department of Hepatobiliary Surgery,Bayannur Hospital,Inner Mongolia Autonomous Regin,Bayannur015002,China;Clinical Medical Research Center of the Affiliated Hospital,Inner Mongolia Medical University,Inner Mongolia Autonomous Regin,Hohhot010050,China)

机构地区：[1]内蒙古自治区巴彦淖尔市医院肝胆胰脾外科,内蒙古巴彦淖尔015002 [2]内蒙古医科大学附属医院临床医学研究中心,内蒙古呼和浩特010050

出　　处：《中国医药导报》2022年第19期41-44,65,共5页China Medical Herald

基　　金：国家自然科学基金资助项目(81960560)。

摘　　要：随着全球肥胖相关的代谢疾病的患病率不断增加,非酒精性脂肪肝病(NAFLD)在肝脏疾病中的所占比例逐渐增加,而由该疾病带来相关致残率和并发症,为患者及社会医疗带来了沉重的负担。非酒精性脂肪肝炎是机体葡萄糖和脂肪代谢紊乱,全身系统性低度炎症,促使脂肪组织(AT)分泌释放促炎和抗炎脂肪因子调节AT-肝轴,脂肪因子在抗炎和促炎过程中的功能不同,影响肝脏转运、分解脂肪能力及肝脏脂肪沉积,调控NAFLD的进展。本文重点对脂联素、瘦素、抵抗素、内脂素、视黄醇结合蛋白4等脂肪因子在NAFLD疾病进展过程中表达水平及作用机制进行综述。随着脂肪因子研究的完善及临床研究的跟进,为脂肪因子治疗NAFLD疾病提供新策略与新思路。With the increasing prevalence of obesity related metabolic diseases in the world, the proportion of nonalcoholic fatty liver disease(NAFLD) in liver diseases is gradually increasing, and the disease brings related disabilities. Complications have brought a heavy burden to patients suffering from the disease and social medical care.Non-alcoholic steatohepatitis is the body’s glucose and fat metabolism disorder, systemic low-grade inflammation.Then pro-inflammatory and anti-inflammatory adipokines, as a hormone of secretion, is secreted by adipose tissue(AT)that compose the AT-liver axis. But the adipokines have different functions between the processes of inflammation and pro-inflammatory. It will be effective in liver transport, fat breakdown ability and liver fat deposition, and regulating the development of NAFLD. This article focuses on the expression level and mechanism of adiponectin, leptin, resistin,visfatin, retinol binding protein 4, and other adipokines in the progression of NAFLD disease. With the improvement of adipokines research and the follow-up of clinical research, new strategies and new ideas are provided for the treatment of adipokines in NAFLD disease.

关 键 词：非酒精性脂肪肝病 非酒精性脂肪肝炎 脂联素 瘦素 

分 类 号：R575.5[医药卫生—消化系统]