69例自身免疫性胃炎证候分布规律的单中心回顾性横断面研究  

Traditional Chinese Medical syndromes in 69 patients with autoimmune gastritis:A single-center retrospective cross-sectional study

作　　者：梁春耕 李静波 肖定洪 杨伟[1] 尚莹莹[1] 郭召平[1] LIANG Chungeng;LI Jingbo;XIAO Dinghong;YANG Wei;SHANG Yingying;GUO Zhaoping(Department of Gastroenterology,Jiading Hospital of Traditional Chinese Medicine,Shanghai,201899,China;Department of Pathology,Jiading Hospital of Traditional Chinese Medicine)

机构地区：[1]上海市嘉定区中医医院牌胃病科,上海201899 [2]上海市嘉定区中医医院病理科,上海201899

出　　处：《中国中西医结合消化杂志》2022年第7期495-499,共5页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：国家自然科学基金项目(No:82174240);中国中医科学院科技创新工程(No:CI2021A01005)。

摘　　要：目的:研究自身免疫性胃炎证候分布规律。方法:采用单中心回顾性横断面调查方法,选取上海市嘉定区中医医院2014—2022年医院信息系统数据,共纳入69例自身免疫性胃炎患者。采集患者胃镜、活检或手术病理、四诊信息(包括症状、舌象和脉象)等数据。采用因子分析、聚类分析方法分析自身免疫性胃炎证候分布规律。结果:共收集到35个症状因子及17个舌脉因子进行分析,排除频率5%的症状因子,共纳人15个症状因子进行因子分析。共提取出6个公因子。将纳入因子分析的15个症状及10个舌脉因子进行系统聚类分析,结合因子分析结果、中医诊疗专家共识意见证候类型,可将本病的证候分为4个类型:脾胃虚弱、脾胃湿热、肝胃不和、阴虚血癌。在此4个证候类型基础上,将上述因子进行K均值聚类分析,归纳为脾胃虚弱型23例(33.33%),脾胃湿热型17例(24.64%),阴虚血癌型16例(23.19%),肝胃不和型13例(18.84%)。结论:自身免疫性胃炎的证候可分为脾胃虚弱、脾胃湿热、肝胃不和、阴虚血癌4型。Objective:To investigate Traditional Chinese Medical syndromes in patients with autoimmune gas-tritis.Methods:A single center retrospective cross-sectional study was completed.A total of 69 autoimmune gas-tritis patients were collected from the hospital information system in Jiading Hospital of Traditional Chinese Medi-cine in 2014-2022.The data,which include gastroscope,biopsy or surgical pathology,and four diagnostic information were analyzed by factor analysis and cluster analysis.Results:Fifty-two pieces of information were collect-ed,including 35 symptoms and 17 data of tongue coating and pulse.A total of 15 symptom factors were included for factor analysis,after symptom factors with a frequency of<<5%were excluded,and six common factors were extracted.15 symptom factors and 10 tongue and pulse factors included in factor analysis were analyzed by sys-tematic cluster analysis.Combined with the results of factor analysis and the consensus of TCM diagnosis and treatment experts,the syndrome types of this disease can be divided into four types:weakness of spleen and stom-ach,damp heat of spleen and stomach,disharmony between liver and stomach,Yin deficiency and blood stasis.Based on the four syndrome types,the above factors were analyzed by K-means cluster analysis.There were 23 cases of spleen stomach weakness type(33.33%),17 cases of spleen stomach damp-heat type(24.64%),16 cases of Yin deficiency and blood stasis type(23.19%),and 13 cases of liver stomach disharmony type(18.84%).Conclusion:The syndromes of autoimmune gastritis can be divided into four types:weakness of spleen and stomach,damp heat of spleen and stomach,disharmony between liver and stomach,Yin deficiency and blood stasis.

关 键 词：自身免疫性胃炎 证侯 因子分析 聚类分析 

分 类 号：R573.3[医药卫生—消化系统]