民族药三子方防治腺瘤性大肠息肉术后复发的临床观察  

Clinical observation on the prevention and treatment of postoperative recurrence of adenomatous colonic polyp by ethnic medicine Sanzifang

作　　者：李忠意[1,2] 朱传旺 商竞宇 田耀洲 魏兰福[1,2] 滑永志[1,2] 张伟[1,2] 姚天琦[1,2] 章细霞 林琳[1,2] LI Zhongyi;ZHU Chuanwang;SHANG Jingyu;HUA Yongzhi;ZHANG Wei;YAO Tianqi;TIAN Yaozhou;WEI Lanfu;ZHANG Xixia;LIN Lin(Department of Digestive,Affiliated Hospital of Integrated Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing,210028,China;Jiangsu Province Academy of Traditional Chinese Medicine)

机构地区：[1]南京中医药大学附属中西医结合医院消化科,南京210028 [2]江苏省中医药研究院

出　　处：《中国中西医结合消化杂志》2022年第7期500-504,共5页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：江苏省中医药研究院青年科学研究项目(No:QNKXYJ202106)。

摘　　要：目的:观察民族药三子方防治腺瘤性大肠息肉术后复发情况。方法:将60例腺瘤性大肠息肉病患.者,均行内镜下治疗术后并予西医常规处理和对症支持治疗,随机均分为2组,每组30例。治疗组以三子方颗粒剂(黄芪、乌梅、石榴子、榼藤子、余甘子、花椒、钩藤、广郁金、甘草)口服治疗;对照组以三子方模拟剂(安慰剂颗粒剂)同方法服用。2次/d,2包/次,早晚分服,治疗周期为12周。记录随访治疗前后各组的临床症状评分,随访观察2组术后半年、1年的息肉复发情况及病理变化。结果:治疗组临床症状评分与术前相比较均降低,差异有统计学意义(P<0.05);对照组症状评分除黏液血便与术前相比较降低外,其余差异均无统计学意义(P>0.05)。2组患者共复发18例,总复发率为30.0%,其中术后1年随访期,治疗组总复发率(13.3%)低于对照组(26.6%),差异有统计学意义(P<0.05)。2组复发病例中,随访半年内未出现息肉复发,至随访1年后复查,复发的息肉病理结果提示腺瘤均为3例,差异无统计学意义(P>0.05)。2组观察期内未出现不良反应。结论:民族药三子方对大肠腺瘤内镜下治疗术后改善临床症状及预防术后复发有明显疗效。Objective:To observe the clinical symptom score and recurrence rate of ethnic medicine Sanzifang after endoscopic treatment of colorectal adenoma.Methods:Sixty patients with adenomatous colonic polyposis were randomly divided into two groups with 30 patients in each group.The treatment group was treated with Sanzifang granule(Astragalus mem'branaceus,plum,pomegranate seeds,cane and cane,Fructus meliformis,Zanthoxylum,Uncaria,Turmeric root,and licorice root).The control group was given placebo granules in the same way.The treatment period was 12 weeks,with two packets each time,twice a day,divided into the morn-ing and evening.The clinical symptom scores of each group before and after follow-up treatment were recorded,and the recurrence and pathological changes of polyps in both groups were observed six months and one year after surgery.Results:The clinical symptom score of the treatment group was significantly lower than that before the operation(P<0.05).Symptom scores in the control group were lower than those before the operation except for mucous blood and stool(P>0.05).There were 18 cases of recurrence in the two groups,and the total recurrence rate was 30.0%,During the 1-year follow-up period,the total recurrence rate in the treatment group(13.3%)was lower than that in the control group(26.6%),and the difference was statistically significant(P<0.05).There were 3 cases of recurrent adenoma in both groups,and the difference was not statistically significant.There were no adverse reactions in the two groups during the observation period.Conclusion:Ethnic medicine Sanzifang has an obvious effect on improving clinical symptoms and preventing recurrence after endoscopic treatment of colorectal adenoma.

关 键 词：三子方 大肠腺瘤 临床症状 复发率 

分 类 号：R574[医药卫生—消化系统]