n-3多不饱和脂肪酸抗肥胖作用的研究进展  

Research Progress of Anti-obesity Effect of n-3 Polyunsaturated Fatty Acids

作　　者：戴秋芹 任静 陈燃 张冰 李祥勇 DAI Qiuqin;REN Jing;CHEN Ran;ZHANG Bing;LI Xiangyong(Institute of Biochemistry and Molecular Biology,Guangdong Medical University,Zhanjiang 524023,China;Key Laboratory for Active Molecules of Department of Education of Guangdong Province,Zhanjiang 524023,China;Department of Plastic Surgery,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524001,China)

机构地区：[1]广东医科大学生物化学与分子生物学研究所,广东湛江524023 [2]广东省教育厅医学生物活性分子研究重点实验室,广东湛江524023 [3]广东医科大学附属医院整形外科,广东湛江524001

出　　处：《医学综述》2022年第15期2938-2944,共7页Medical Recapitulate

基　　金：广东省基础与应用基础研究基金自然科学基金(2022A1515012299);广东省普通高校特色创新类项目(2021KTSCX034);广东省医学科研基金项目(A2020366);广东省中医药局科研项目(20201187)。

摘　　要：肥胖不仅是一种多病因基础慢性疾病,还是诱发多种疾病的高危因素。n-3多不饱和脂肪酸(PUFAs)是人体重要的抗炎性细胞因子和必需营养素,目前被认为可通过抗炎作用、抑制脂肪生成和促进棕色脂肪组织形成等参与肥胖的防治。脂肪干细胞作为脂肪组织中一类多能干细胞,具有定向分化为成熟脂肪细胞的特性和多种分化潜能及免疫调节的功能,与肥胖和2型糖尿病关系密切。n-3 PUFAs可影响脂肪干细胞的成脂分化,但具体作用机制尚不明确。Obesity is not only a chronic disease with multiple etiologies,but also a high risk factor for inducing a variety of diseases.n-3 polyunsaturated fatty acids(n-3 PUFAs)are important anti-inflammatory cytokines and essential nutrients for human body.It is currently believed that n-3 PUFAs can participate in the prevention and treatment of obesity through anti-inflammatory effects,inhibiting adipogenesis and promoting fat browning.Adipose-derived stem cells,as a kind of pluripotent stem cells in adipose tissue,have the characteristics of directed differentiation into mature adipocytes,diversified differentiation potential and immunomodulatory functions,and are closely related to obesity and type 2 diabetes mellitus.Studies have shown that n-3 PUFAs can affect adipogenic differentiation of adipose stem cells,although the specific role and mechanism are not clear yet.

关 键 词：肥胖 N-3多不饱和脂肪酸 脂肪干细胞 成脂分化 

分 类 号：R589.2[医药卫生—内分泌]